Chaperones aren't just for high-school homecoming dances. Cells have chaperones as well, chaperone proteins that ensure newly made proteins are properly folded. If protein folding goes awry, diseases associated with misfolded proteins such as Alzheimer's and Parkinson's can arise. But if one set of chaperones can throw a wet blanket on a school dance, imagine a second set of co-chaperones just to keep the chaperones in check. That's the growing picture in cellular chaperoning as folding guardians of the cell turn out to have guardians of their own.
Back from the undead, the 2014 "Zombie Cellslam," the Public Information Committee's stand-up science slam, is slouching toward Philadelphia where it will take the stage again at an Annual Meeting of the ASCB for the first time in five remarkably peaceful years. No more. The 2014 Zombie Cellslam, so named because it will not die, is set for Monday evening, December 10, at the joint ASCB/IFCB meeting in the Pennsylvania Convention Center. It will offer a variety of wit, music, and outrageously amusing competition plus free popcorn and a cash bar.
It is a truth all but universally acknowledged that a eukaryotic cell entering mitosis must be in want of the canonical proteins for mitotic checkpoints. And then there is Giardia intestinalis. A notorious flagellate pathogen, this binucleate protist belongs to one of the major eukaryotic lineages now called the "Excavates." Like all other Excavates, Giardia is weird, says Zacheus Cande of the University of California, Berkeley, but weird in a good way because of its ancient evolutionary divergence from the better-known branch of eukaryotes where everything from humans to yeast hang out.
The secret is out. There is life beyond the lab or the classroom for someone with a PhD in molecular biology, especially in the biotech and pharmaceutical industry. And yet many of these business careers have little to do directly with bench expertise but instead call on doctoral level training in analysis, planning, and communication. Those are the key skills that serve Jason Huhn and Danielle Haney, recent PhD graduates who are happily pursuing fast-paced, well-paid office-based careers as consultants.