"A" is for axolotl, a funky looking salamander regarded by the Aztecs as a delicacy and by cell biologists who believe it could hold the key for unlocking regeneration. The axolotl (Ambystoma mexicanum) is not new to science. It's been used in the lab for over 150 years and like many lab animal systems, the axototl has had peaks and valleys of popularity. But David Gardiner, professor at University of California, Irvine (UCI) and an ASCB member, has been working on regeneration with axolotls for over 30 years. It was his wife, Sue Bryant, who is also a UCI professor and fellow ASCB member, who first introduced Gardiner to this nontraditional animal model.
When it comes to policy making in Washington, DC, what does not happen is sometimes as important as what does. Such was the case last month when the U.S. Senate and the U.S. House of Representatives passed the Digital Accountability and Transparency Act (DATA Act), which is intended to increase the accountability and transparency of federal spending. Absent from the bill were severe restrictions on the ability of federal scientists to participate in scientific meetings. The ASCB played a key role in dodging this bullet.
Forget the Super Bowl. If you want to draw a HUGE crowd, throw a science and engineering open house in the Washington, DC, convention center. But get ready to stand back. This weekend, the USA Science & Engineering Festival attracted over 325,000 fans. Yes, you read that correctly—325,000 kids and adults turning out for a science event. Inside the Walter E. Washington Convention Center, they loaded up on gumdrop molecules or paper mutant Drosophilae. They wore Eppendorf tubes of precipitated DNA around their necks or carried plastic condiment cups filled with soil and germinating seeds. Some had "infection" stickers on their shirts, part of a Virus Tracker game to illustrate disease transmission. Fortunately for the massive crowd the event had more than 3,000 science, engineering, technology and math (STEM) activities inside the cavernous center waiting to soak up their attention.
We still talk about guinea pigs as experimental subjects yet you'd have a hard time finding one in a modern research laboratory. Guinea pigs were first used in biomedical research in the late 19th century, playing a major role in establishing the germ theory, identifying pathogens, linking vitamin C insufficiency to scurvy, and modeling diabetes and pre-eclampsia. The guinea pig metaphor lives on but today, mice, rats, fruit flies, nematodes, and zebrafish dominate as model animals. But there are many new model animals on the research horizon, chosen because they can model human diseases in novel ways or because they have special abilities that humans lack. In this series, we will explore a few of the nontraditional animal models, and their potential in the lab.