We still talk about guinea pigs as experimental subjects yet you'd have a hard time finding one in a modern research laboratory. Guinea pigs were first used in biomedical research in the late 19th century, playing a major role in establishing the germ theory, identifying pathogens, linking vitamin C insufficiency to scurvy, and modeling diabetes and pre-eclampsia. The guinea pig metaphor lives on but today, mice, rats, fruit flies, nematodes, and zebrafish dominate as model animals. But there are many new model animals on the research horizon, chosen because they can model human diseases in novel ways or because they have special abilities that humans lack. In this series, we will explore a few of the nontraditional animal models, and their potential in the lab.

The Kaluza Prizes to honor the best in graduate student bioscience research are growing. In announcing the opening of the 2014 Kaluza Prize competition, the American Society for Cell Biology (ASCB), in collaboration with Beckman Coulter Life Sciences, said that the awards will increase to $5,000, $3,000, and $1,000 in ranked order for the top three winners.

ASCB Women in Cell Biology committee member Ora Weisz, of the University of Pittsburgh, was inducted last week into Johns Hopkins University's (JHU) Society of Scholars. The Society recognizes accomplished former JHU postdoctoral fellows or visiting faculty who have gained marked distinction elsewhere. Just over 600 people have been inducted into the society since 1969. Weisz joined distinguished academics from around the world for an induction ceremony at JHU's Peabody Institute on April 7.

Calling it "a recipe for long-term decline," four of the nation's most distinguished cell biologists describe the present U.S. system of biomedical research as "unsustainable" and "hypercompetitive," calling for a sweeping rebalancing of bioscience education, funding, and direction. In a "Perspective" just published in PNAS, Bruce Alberts, Marc Kirschner, Shirley Tilghman, and Harold Varmus advocate reforms in the scientific workforce with a gradual reduction in the number of students accepted into biomedical PhD programs and an increase in compensation for postdoctoral fellows but limits on the length of fellowships. Alberts et al. propose a reordering of government research funding priorities, using sunset provisions to rein in large, ongoing research programs while favoring proposals from young investigators that "emphasize originality and risk-taking, especially in new areas of science." They support the recent controversial decision by NIH to look at the total grant portfolio of laboratories receiving more than $1 million a year when evaluating any new proposals.

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