It's been nearly 14 years since the primary cilium pushed its way into cell biology's center ring with the discovery that this "irrelevant" vestigial organelle was connected to a common and fatal human disorder, polycystic kidney disease (PKD). In the years since, a long list of diseases and disorders have been classified as ciliopathies while the primary cilium currently has 2,347 citations on PubMed.
It was an all-or-nothing moment. Titia de Lange, a newly hired assistant professor at the Rockefeller University, had months of prep work and her entire grant's supply budget in hand as she waited to cross York Avenue, the busy north-south street on Manhattan's Upper East Side that separates Rockefeller from Memorial Sloan-Kettering Cancer Center, where a collaborator was waiting to sequence de Lange's protein distillate. "We walked with all the protein we had from 1,500 liters of HeLa cells," de Lange recalled. "If we had tripped it would have been a problem. "It was a potentially self-destructive experiment, but it worked."
Consider it progress but many in Congress are coming around to the idea that the current system for funding the U.S. National Institutes of Health (NIH) and other federal science programs isn't working. Getting everyone on the Hill to agree what should be done to protect research funding is another matter. Now, one senator has come up with a daring new idea on how to shelter biomedical research funding from the budgetary hurricanes blowing through both chambers.
Supposedly, 200 million people are out there blogging. Unsurprisingly, many of them are working scientists, some are even cell biologists. It's one of the encouraging features of the evolving science writing ecosystem that scientists can write directly about their lives and their work. Some scientists use their blogs as podiums, some as pulpits, and some as stand-up mikes for riffs on the day-to-day research world of dirty glassware, shaky funding, and bad behavior.