It's been nearly 14 years since the primary cilium pushed its way into cell biology's center ring with the discovery that this "irrelevant" vestigial organelle was connected to a common and fatal human disorder, polycystic kidney disease (PKD). In the years since, a long list of diseases and disorders have been classified as ciliopathies while the primary cilium currently has 2,347 citations on PubMed.
A yogurt producer with concerns, a puzzling aspect of bacterial genomes, a discussion over coffee, and a new MIT faculty member so youthful that he was mistaken for a freshman—these are a few links in the chain of discovery that led to CRISPR, today's hottest genetic rewriting technology. It stands for Clustered Regularly Interspaced Short Palindromic Repeats, and CRISPRs are changing biological research by making it easier than ever to edit genomes, opening whole fields to new possibilities in experiments and likely providing new treatments for complex diseases.
CHICAGO—The "Triple A-S" meeting is like no other scientific gathering in that it is not really for scientists but for journalists who follow science. Scientists do come to present talks or to serve on AAAS governing sections, but to understand the meeting's central purpose, think of AAAS as the world's largest annual science press conference.
For those who think scientific discoveries pop up overnight, consider Tom Rapoport's tale of the holiday carp and how it led him to study the translocation channel through which proteins, such as insulin, are secreted. Rapoport's latest discovery starts with a fish 30 years ago and ends, or at least continues, this month with a publication in Nature of the first x-ray structure of an open protein translocation channel.
John Pringle has been going to different sorts of meetings this last decade. He is still a regular at the ASCB Annual Meeting and at smaller yeast biology gatherings. Indeed he was in New Orleans for the ASCB Annual Meeting in December to receive the E.B. Wilson Medal, the ASCB's highest scientific honor, for his pioneering work on cell polarization and cytokinesis. But Pringle also goes, when he can, to the International Coral Reef Symposium, the Society for Microbial Ecology, and the International Symbiosis Society. He still has a small yeast group in his lab although his other interests have represented the majority since 2007. He is becoming known at these marine biology and ecology meetings, but Pringle says that he wishes there were more cell biologists there. John Pringle aims to correct that.
Biologists are passionate about papers. Here we ask an ASCB member to pick two journal articles that were important, either personally or scientifically, and to answer—briefly and informally—three questions: Why did you pick this paper? What's it about? What does it mean to you?
Making pluripotent stem cells, cells with the ability to turn into almost any cell type, is easier than ever, according to new papers published this week in Nature. Just add stress.
In the "big data" realms of genome sequencing, there are many surprises left to be untangled. A new bioinformatics paper published January 10 in Nature Chemical Biology unwinds one—a new class of RNA-catalysts.
Modeling membranes, nano-magnets to control cell activity, and a gain-of-function protein behind a severe progressive brainstem disorder were hot topics at the 2013 ASCB Annual Meeting in New Orleans, December 14-18. This year, ASCB continued the tradition of weaving two scientific threads—biophysics and medicine—through many of the 254 science presentations.
Mathieu Coppey imagines using tiny magnets to move cells within living organisms. Coppey, a researcher at the Institut Curie in Paris, isn't envisioning a modern day version of "magnet therapy" touted a century ago by quack medical practitioners. Instead Coppey is using nanoparticle-size magnets to manipulate processes in cells.