Danger from the Wild: HIV, Can We Conquer It?

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Danger from the Wild: HIV, Can We Conquer It?
David Baltimore, Feb. 2007
California Institute of Technology

Lecture Overview
In part 2, I describe the growing health problem that is facing the world with the spread of HIV and the limitations of current drug therapies and vaccine strategies. We need new ideas for tackling this problem. Here and in the next segment, I describe bold strategies of using gene therapy to conquer HIV, The approach that I describe in this segment involves gene therapy to produce short hairpin RNAs (siRNA) that target the destruction of a critical co-receptor of HIV, which the viruses that needs to infect cells. I discuss initial proof-of-principle experiments that suggest this approach might be feasible and the next steps needed to develop this idea into a real therapy.
Part 2: Why Gene Therapy Might be a Reasonable
Tool for Attacking HIV (30:08)

Click image above to start seminar in 320x240 format
Click here to view in larger 640x480 format*
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Downloads in alternative formats:
(To Save, Right Click a link below and select "Save Target/Link As")
QuickTime (56mb)     MP4 (353mb)     iPod Video (353mb)
PowerPoint Slides 1/page (604kb)     PowerPoint Slides 6/page (317kb)

MP4 (364mb)

Format Descriptions
Download Accelerator/Resume Broken Downloads Software

Part 1: Introduction to Viruses: HIV and Non-equilibrium Viruses (34:06)

Part 3: The Grand Challenge: Engineering Immunity (18:51)

Speaker Bio    Related Articles

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Lecture Overview In part 2, I describe the growing health problem that is facing the world with the spread of HIV and the limitations of current drug therapies and vaccine strategies. We need new ideas for tackling this problem. Here and in the next segment, I describe bold strategies of using gene therapy to conquer HIV, The approach that I describe in this segment involves gene therapy to produce short hairpin RNAs (siRNA) that target the destruction of a critical co-receptor of HIV, which the viruses that needs to infect cells. I discuss initial proof-of-principle experiments that suggest this approach might be feasible and the next steps needed to develop this idea into a real therapy.	Part 2: Why Gene Therapy Might be a Reasonable Tool for Attacking HIV (30:08) Click image above to start seminar in 320x240 format Click here to view in larger 640x480 format* QuickTime 7 Required 640x480 System Requirements (there may be a few seconds delay before seminars start) Downloads in alternative formats:* (To Save, Right Click a link below and select "Save Target/Link As") QuickTime (56mb) MP4 (353mb) iPod Video (353mb) PowerPoint Slides 1/page (604kb) PowerPoint Slides 6/page (317kb) MP4 (364mb) Format Descriptions Download Accelerator/Resume Broken Downloads Software
Part 1: Introduction to Viruses: HIV and Non-equilibrium Viruses (34:06) Part 3: The Grand Challenge: Engineering Immunity (18:51) Speaker Bio Related Articles