Adhesion, Signaling and Cancer - Part 1, Mary C. Beckerle

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Adhesion, Signaling and Cancer
Mary C. Beckerle, July 2007
Huntsman Cancer Institute, University of Utah

Lecture Overview
Cell-substratum adhesion is mediated by integrins, a family of transmembrane, heterodimeric, extracellular matrix receptors that are concentrated at focal adhesions. Integin engagement influences a variety of signaling pathways and regulates cell behaviors including motility, proliferation, and survival. Disturbance of normal integrin function is associated with a variety of pathologic conditions including cancer. In the first segment of my seminar, I provide a broad overview of the cancer problem for a lay audience. Advances in our understanding of cancer as a genetic disease are discussed. The influence of cell adhesion on control of cell growth is reviewed
Part 1: Understanding Cancer From Its Beginnings (36:04)

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Format Descriptions
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Part 2: Discovery and Characterization of a Focal Adhesion Protein Implicated in Tumor Progression (50:54)

Part 3: Focal Adhesions as Stress Sensors (30:57)

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Lecture Overview Cell-substratum adhesion is mediated by integrins, a family of transmembrane, heterodimeric, extracellular matrix receptors that are concentrated at focal adhesions. Integin engagement influences a variety of signaling pathways and regulates cell behaviors including motility, proliferation, and survival. Disturbance of normal integrin function is associated with a variety of pathologic conditions including cancer. In the first segment of my seminar, I provide a broad overview of the cancer problem for a lay audience. Advances in our understanding of cancer as a genetic disease are discussed. The influence of cell adhesion on control of cell growth is reviewed	Part 1: Understanding Cancer From Its Beginnings (36:04) Click image above to start seminar in 320x240 format Click here to view in larger 640x480 format* QuickTime 7 Required 640x480 System Requirements (there may be a few seconds delay before seminars start) Downloads in alternative formats:* (To Save, Right Click a link below and select "Save Target/Link As") QuickTime (66mb) MP4 (421mb) iPod Video (421mb) PowerPoint Slides 1/page (1mb) PowerPoint Slides 6/page (652kb) Format Descriptions Download Accelerator/Resume Broken Downloads Software
Part 2: Discovery and Characterization of a Focal Adhesion Protein Implicated in Tumor Progression (50:54) Part 3: Focal Adhesions as Stress Sensors (30:57) Speaker Bio Related Articles