Adhesion, Signaling and Cancer - Part 3, Mary C. Beckerle

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Adhesion, Signaling and Cancer
Mary C. Beckerle, July 2007
Huntsman Cancer Institute, University of Utah

Lecture Overview
In the third segment of my seminar, I address a new frontier in cell biology, that is how cells respond to mechanical information. Cells and tissues are exposed to physical forces in vivo and excessive mechanical stress leads to a variety of pathological consequences. I describe a system for exposing cells to controlled mechanical stress and discuss the stretch response. We have discovered that the focal adhesion protein, zyxin, is exquisitely sensitive to mechanical stimulation and is required for the ability of cells to reinforce the actin cytoskeleton when challenged by exposure to cyclic stretch.
Part 3: Focal Adhesions as Stress Sensors (30:57)

Click image above to start seminar in 320x240 format
Click here to view in larger 640x480 format*
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(there may be a few seconds delay before seminars start)

Downloads in alternative formats:
(To Save, Right Click a link below and select "Save Target/Link As")
QuickTime (57mb)     MP4 (361mb)     iPod/iPhone Video (361mb)
PowerPoint Slides 1/page (1.2mb)     PowerPoint Slides 6/page (554kb)

Format Descriptions
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Part 1: Understanding Cancer From Its Beginnings (36:04)

Part 2: Discovery and Characterization of a Focal Adhesion Protein Implicated in Tumor Progression (50:54)

Speaker Bio    Related Articles

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Lecture Overview In the third segment of my seminar, I address a new frontier in cell biology, that is how cells respond to mechanical information. Cells and tissues are exposed to physical forces in vivo and excessive mechanical stress leads to a variety of pathological consequences. I describe a system for exposing cells to controlled mechanical stress and discuss the stretch response. We have discovered that the focal adhesion protein, zyxin, is exquisitely sensitive to mechanical stimulation and is required for the ability of cells to reinforce the actin cytoskeleton when challenged by exposure to cyclic stretch.	Part 3: Focal Adhesions as Stress Sensors (30:57) Click image above to start seminar in 320x240 format Click here to view in larger 640x480 format* QuickTime 7 Required 640x480 System Requirements (there may be a few seconds delay before seminars start) Downloads in alternative formats:* (To Save, Right Click a link below and select "Save Target/Link As") QuickTime (57mb) MP4 (361mb) iPod/iPhone Video (361mb) PowerPoint Slides 1/page (1.2mb) PowerPoint Slides 6/page (554kb) Format Descriptions Download Accelerator/Resume Broken Downloads Software
Part 1: Understanding Cancer From Its Beginnings (36:04) Part 2: Discovery and Characterization of a Focal Adhesion Protein Implicated in Tumor Progression (50:54) Speaker Bio Related Articles