Telomeres and Telomerase: Their Implications in Human Health and Disease

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Telomeres and Telomerase: Their Implications in Human Health and Disease
Elizabeth Blackburn, June 2008
University of California, San Francisco/Department of Biochemistry and Biophysics

Lecture Overview
Telomerase, a specialized ribonucleprotein reverse transcriptase, is important for long-term eukaryotic cell proliferation and genomic stability, because it replenishes the DNA at telomeres. Thus depending on cell type telomerase partially or completely (depending on cell type) counteracts the progressive shortening of telomeres that otherwise occurs. Telomerase is highly active in many human malignancies, and a potential target for anti-cancer approaches. Furthermore, recent collaborative studies have shown the relationship between accelerated telomere shortening and life stress and that low telomerase levels are associated with six prominent risk factors for cardiovascular disease.
Part 1: The Roles of Telomeres and Telomerase (48:27)

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Part 2: Telomeres and Telomerase in Human Stem Cells and in Cancer (26:58)

Part 3: Stress, Telomeres and Telomerase in Humans (45:58)

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Lecture Overview Telomerase, a specialized ribonucleprotein reverse transcriptase, is important for long-term eukaryotic cell proliferation and genomic stability, because it replenishes the DNA at telomeres. Thus depending on cell type telomerase partially or completely (depending on cell type) counteracts the progressive shortening of telomeres that otherwise occurs. Telomerase is highly active in many human malignancies, and a potential target for anti-cancer approaches. Furthermore, recent collaborative studies have shown the relationship between accelerated telomere shortening and life stress and that low telomerase levels are associated with six prominent risk factors for cardiovascular disease.	Part 1: The Roles of Telomeres and Telomerase (48:27) Click image above to start seminar in 320x240 format Click here to view in larger 640x480 format* QuickTime 7 Required 640x480 System Requirements (there may be a few seconds delay before seminars start) Downloads in alternative formats:* (To Save, Right Click a link below and select "Save Target/Link As") QuickTime (91mb) MP4 (558mb) iPod/iPhone Video (558mb) PowerPoint Slides 3/page (348kb) Format Descriptions Download Accelerator/Resume Broken Downloads Software
Part 2: Telomeres and Telomerase in Human Stem Cells and in Cancer (26:58) Part 3: Stress, Telomeres and Telomerase in Humans (45:58) Speaker Bio Related Articles