Role of the Neural Crest in Vertebrate Development and Evolution

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Role of the Neural Crest in Vertebrate Development and Evolution
Nicole Le Douarin, March 2008
CNRS and Collège de France, Paris

Lecture Overview
The neural crest (NC) is a transitory structure of the Vertebrate embryo. It forms when the neural tube closes through the epithelio- mesenchymal transition of the cells in the joining neural folds. Its constitutive cells are endowed of migratory capacities and are highly pluripotent. NC cells migrate in the developing embryo along definite pathways, at precise periods of time during embryogenesis and settle in elected sites in the body where they develop into a large of cell types. The paramount role played by the NC in the development of higher Vertebrates has been deciphered in the last decades through the use of cell marking technique that I devised in 1969. This technique is based on the constrution of chimeric embryos between two species of birds the chick (Gallus gallus) and the Japanese quail (Coturnix coturnix japonica) whose cells can be distinguished by the structure of their interphase nucleus or by applying species specific monoclonal antibodies on chimeric tissues.
Part 1: The Quail Chick Marker System and Its Use to Study the Ontogeny of the Neural Crest (24:45)

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Part 2: The Role of the Neural Crest in Head Development and in Vertebrate Evolution (30:04)

Part 3: The Molecular Control of the Neural Crest Contribution to Craniofacial and Brain Development (36:10)

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Lecture Overview The neural crest (NC) is a transitory structure of the Vertebrate embryo. It forms when the neural tube closes through the epithelio- mesenchymal transition of the cells in the joining neural folds. Its constitutive cells are endowed of migratory capacities and are highly pluripotent. NC cells migrate in the developing embryo along definite pathways, at precise periods of time during embryogenesis and settle in elected sites in the body where they develop into a large of cell types. The paramount role played by the NC in the development of higher Vertebrates has been deciphered in the last decades through the use of cell marking technique that I devised in 1969. This technique is based on the constrution of chimeric embryos between two species of birds the chick (Gallus gallus) and the Japanese quail (Coturnix coturnix japonica) whose cells can be distinguished by the structure of their interphase nucleus or by applying species specific monoclonal antibodies on chimeric tissues.	Part 1: The Quail Chick Marker System and Its Use to Study the Ontogeny of the Neural Crest (24:45) Click image above to start seminar in 320x240 format Click here to view in larger 640x480 format* QuickTime 7 Required 640x480 System Requirements (there may be a few seconds delay before seminars start) Downloads in alternative formats:* (To Save, Right Click a link below and select "Save Target/Link As") QuickTime (47mb) MP4 (286mb) iPod/iPhone Video (286mb) PowerPoint Slides 3/page (3.2mb) Format Descriptions Download Accelerator/Resume Broken Downloads Software
Part 2: The Role of the Neural Crest in Head Development and in Vertebrate Evolution (30:04) Part 3: The Molecular Control of the Neural Crest Contribution to Craniofacial and Brain Development (36:10) Speaker Bio Related Articles