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Advances in Computational Protein Design: Design and Testing of Protein Combinatorial Libraries Stephen L. Mayo, Jan. 2008 California Institute of Technology |
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| Lecture Overview In this lecture, I discuss the challenges of designing new proteins that fold into a particular structure or perform a particular function. One method is to computationally design a protein based solely upon our knowledge of amino acids and protein folding, a hard task but one which has had recent successes. Another approach is to screen combinatorial libraries of proteins for a desired function. In particular, I will discuss how structure-based computational methods can allow for high mutation rate (to explore a diversity of function) while maintaining stably folded structures (a necessity to preserve stability and function). In the last part of my talk, I discuss how we have used protein libraries to design a new blue fluorescent protein. |
Part 1: Introduction to Protein Design by Computation (31:09)
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 Part
2: Designing Protein Libraries and an Example of Making a Better Fluorescent Protein (33:50)
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