The Problem of Regeneration - Part 1, Alejandro Sánchez Alvarado

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The Problem of Regeneration
Alejandro Sánchez Alvarado, Jan. 2007
HHMI, Dept. of Neurobiology & Anatomy, University of Utah School of Medicine

Lecture Overview
Regeneration has fascinated philosophers and scientists since the beginning of history. The wide but uneven distribution of regenerative capacities among multicellular organisms is puzzling, and the permissive/inhibitory mechanisms regulating this attribute in animals remain a mystery. In the first part of this lecture, I will provide a general history of regeneration research from ancient Greece to the beginning of the 20th century. Key concepts will be introduced in their appropriate historical context, and many of the unanswered questions put forward by the problem of regeneration will be discussed. Planarians have attracted the attention of generations of biologists. It is not hard to see why: cut a worm into two fragments and each fragment regenerates a complete organism. Cut it into 8 fragments and each individual fragment will go on to regenerate a complete animal.
Part 1: A Brief (Natural) History of Regeneration (32:38)

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Part 2: Principles of Planarian Regeneration (32:49)

Part 3: Molecular Basis of Regeneration: Planarians as a Model System (43:54)

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Lecture Overview Regeneration has fascinated philosophers and scientists since the beginning of history. The wide but uneven distribution of regenerative capacities among multicellular organisms is puzzling, and the permissive/inhibitory mechanisms regulating this attribute in animals remain a mystery. In the first part of this lecture, I will provide a general history of regeneration research from ancient Greece to the beginning of the 20th century. Key concepts will be introduced in their appropriate historical context, and many of the unanswered questions put forward by the problem of regeneration will be discussed. Planarians have attracted the attention of generations of biologists. It is not hard to see why: cut a worm into two fragments and each fragment regenerates a complete organism. Cut it into 8 fragments and each individual fragment will go on to regenerate a complete animal.	Part 1: A Brief (Natural) History of Regeneration (32:38) Click image above to start seminar in 320x240 format Click here to view in larger 640x480 format* QuickTime 7 Required 640x480 System Requirements (there may be a few seconds delay before seminars start) Downloads in alternative formats:* (To Save, Right Click a link below and select "Save Target/Link As") QuickTime (61mb) MP4 (382mb) iPod Video (382mb) Format Descriptions Download Accelerator/Resume Broken Downloads Software
Part 2: Principles of Planarian Regeneration (32:49) Part 3: Molecular Basis of Regeneration: Planarians as a Model System (43:54) Speaker Bio Related Articles