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Cytoskeletal
Motor Proteins Ron Vale, July 2007 HHMI /Dept of Cellular and Molecular Pharmacology, University of California, San Francisco |
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| Lecture Overview
The third (last) part of the lecture is on mitosis, the process by which chromosomes are aligned and then segregated during cell division. I will describe our efforts to find new proteins that are important for mitosis through a high throughput RNAi screen. I will discuss how we technically executed the screen and then focus on new proteins that are we discovered that are involved in generating the microtubules that compose the mitotic spindle. I also discuss the medical importance of studying mitosis, including the development of drugs targeted to mitotic motor proteins, which are currently undergoing testing in clinical trials. |
Part 3: Mining the Genome for Mitotic Treasures (33:41)
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 Part
2: Single Molecule Approaches for Understanding Molecular Motors (25:20)
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