Apoptosis - Part 1, Xiaodong Wang

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Apoptosis
Xiaodong Wang, June 2007
Howard Hughes Medical Institute and Department of Biochemistry, UT-Southwestern Medical Center

Lecture Overview
Apoptosis a form of programmed cell death that plays important roles during animal development, immune response, elimination of damaged cells, and maintenance of tissue homeostasis. Apoptosis is executed by intracellular proteases named caspases that are activated during the onset of apoptosis by extrinsic and intrinsic pathways. The intrinsic pathway is triggered by the release of proteins such as cytochrome c from mitochondria to cytosol and the extrinsic pathway is activated by the binding of death-inducing cytokines such as Tumor Necrosis Factor to its receptor at cell surface. Both pathways are regulated at multiple steps to ensure proper apoptosis.
Part 1: Introduction to Apoptosis (26:15)

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Part 2: Factors Involved in the Intrinsic Pathway of Apoptosis (27:39)

Part 3: Extrinsic Pathway and Regulation of Apoptosis (23:59)

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Lecture Overview Apoptosis a form of programmed cell death that plays important roles during animal development, immune response, elimination of damaged cells, and maintenance of tissue homeostasis. Apoptosis is executed by intracellular proteases named caspases that are activated during the onset of apoptosis by extrinsic and intrinsic pathways. The intrinsic pathway is triggered by the release of proteins such as cytochrome c from mitochondria to cytosol and the extrinsic pathway is activated by the binding of death-inducing cytokines such as Tumor Necrosis Factor to its receptor at cell surface. Both pathways are regulated at multiple steps to ensure proper apoptosis.	Part 1: Introduction to Apoptosis (26:15) Click image above to start seminar in 320x240 format Click here to view in larger 640x480 format* QuickTime 7 Required 640x480 System Requirements (there may be a few seconds delay before seminars start) Downloads in alternative formats:* (To Save, Right Click a link below and select "Save Target/Link As") QuickTime (50mb) MP4 (307mb) iPod Video (307mb) Format Descriptions Download Accelerator/Resume Broken Downloads Software
Part 2: Factors Involved in the Intrinsic Pathway of Apoptosis (27:39) Part 3: Extrinsic Pathway and Regulation of Apoptosis (23:59) Speaker Bio Related Articles