|39th ASCB Annual Meeting|
Washington Convention Center
Sunday, December 12, 2:00 p.m.
Rep. Connie Morella (R-MD) and Larry Goldstein of UCSD will present "Congress 101: How and Why to Talk to Your Congressional Representative." The presentation, organized by the ASCB Public Policy Committee, will demonstrate how scientists can constructively engage their Representatives. Audience participation is encouraged. Refreshments will be served.
Tuesday, December 14, 1:00 p.m.
Frank Solomon (Moderator), Massachusetts Institute of Technology
The second annual career panel will feature six scientists, each of whom recently began an independent career after training in cell biology. Their remarks and discussion with the audience will include: how they found their current jobs, how they would suggest preparing for a job search, what about their training turned out to be relevant, and what their jobs are like on a daily basis. Audience members who are thinking about their own career choices or who have relevant experiences are especially invited to contribute to the discussion.
1999 ASCB Program CommitteeDavid Drubin, Chair
Young UK Cell Biologist Award
Fanni Gergely, a PhD student in Jordan Raff's laboratory at the Wellcome CRC Institute at the University of Cambridge, has been named the British Society for Cell Biology's 1999 Young Cell Biologist of the Year. Her award includes travel and registration for the ASCB Annual Meeting in December. Gergely's research focuses on the characterization of novel microtubule-associated and centrosomal proteins in Drosophila and mammalian cells.
ASCB Receives Funding for Women's Conference
The ASCB received a grant of nearly $50,000 from the NIH National Institute on Environmental Health Sciences and the NIH Office for Research on Women's Health to sponsor a workshop on the careers of women in science. The workshop, which will focus on the role of scientific societies in promoting successful strategies for career development, will be held as a satellite to the ASCB Annual Meeting in Washington this year.
1999 MARC Scholarship Awards
Five institutions were awarded a FASEB/MARC Scholarship for attendance of one faculty member (in bold) and two students at the ASCB Annual Meeting in December:
Special Interest Subgroup Meetings
Saturday, December 11
Washington Convention Center
1:00 PM — 5:00 PM
Cell Biological Applications of Atomic Force Microscopy
The atomic force microscope (AFM) is emerging as a powerful tool in cell biology. The aim of this subgroup session is two-fold: to educate the non-specialist in how the AFM works and how it is being used, and to present recent results at the cutting edge of the technology. The session will begin with a general introduction to the instrumentation and basic modes of operation. This will be followed by presentations in five general application areas. Each of these presentations will begin with a general introduction, followed by recent results in that area.
Cellular Biology of Gap Junction Channels
Present in virtually all cell types in animals ranging from coelenterates to humans, gap junctions are involved in a variety of fundamental processes including regulation of cellular differentiation, growth control, embryonic development and specialized tissue function. Defects in the proteins that comprise gap junctions (connexins) have recently been linked to several human diseases. The proposed session will be the 7th consecutive meeting for this well-attended subgroup at ASCB and will address new developments in our understanding of gap junction diversity, assembly, regulation, channel structure/function, and role in physiological processes.
In Vitro Myogenesis: Models of Development and Disease
Central to the form and function of muscle are the myofibrils that provide the cytoskeletal structure and the contractile force. Despite all that has been learned about myofibrillogenesis over the last 100 years, the challenges of identifying the essential steps involved in this process and of understanding how the process is initiated and controlled are still unmet. A major approach has been to culture cells from embryonic, neonatal or adult cardiomyocytes. This session will present several short talks on the use of different systems and approaches to study myofibrillogenesis. Audience participation will be encouraged by a general discussion of myofibrillogenesis at the end of the platform presentations.
Latest Technical Developments in Live Cell Imaging with GFP
Subgroup D Schedule of Talks
It is now routine to record the dynamic behavior of proteins in living cells. However, most of the analysis of these time-lapse images to date has been limited to simple visual interpretation - just watching movement and changes in distribution, and then commenting on them.
This subgroup meeting will focus on an emerging field–the quantitative numerical analysis of cellular dynamics. Presentations drawn from a diverse body of cell biological areas will focus on technical aspects related to four major areas of interest:
Refreshments will be served.
MAGUKs and PDZs
Membrane-associated Guanylate Kinase homologs (MAGUKs) appear to be an important class of scaffolding proteins responsible for clustering and organizing transmembrane proteins and other elements of signal transduction pathways in animal cells. One of the common protein interaction domains in MAGUKs, called the PDZ domain, also exists in a large number of other proteins where it also mediates protein-protein interaction. This meeting will explore the diversity of these proteins and domains, especially the question of whether the protein interactions are dynamic and regulated, and, if so, what other molecules are important for these regulatory mechanisms. 20-minute presentations will include time for questions.
Mechanisms of Cell Division as Revealed by Imaging Studies
Cell division is a very important process in cell biology. The mechanisms of cell division are currently under active investigation. One of the most useful approaches is to use imaging techniques with which one can study the dynamic distribution and reoganization of critical molecules in living cells. Recently, great progress has been made in developing new imaging methods (including GFP and new fluorescent indicators) that have significantly increased the power of the imaging techniques. Using these techniques, we have obtained new insight into the cellular mechanisms that control the various mitotic events. It will be of interest to the cell biology community to know about this recent progress. Furthermore, this subgroup meeting will serve as a useful forum for investigators to share their current views on the most critical issues involved in the regulation of cell division.
Membrane Fusion: Machinery and Mechanism
Membrane fusion is a fundamental cellular process regulating intracellular transport, neurotransmission, enzyme secretion and hormone release, to name a few. Additionally, knowledge of how opposing bilayers fuse will further our understanding of cellular entry/exit of viruses, and provide us with the facts to develop the next generation of drug delivery systems. In the last decade and especially in the last year or two, great strides have been made in our understanding of the molecular machinery and mechanism of membrane fusion. This Special Interest Subgroup will bring together investigators in the field to discuss and participate with experts in the area. Several speakers who are investigators in the field will cover new developments and discuss some of the emerging technology helping in the study of this vital cellular process.
Raftology: Lipid Microdomains and Membrane Function
Subgroup H — Room 14
Organizers: Michael J. Saxton, University of California, Davis, David Holowka, Cornell University, and Chiara Zurzolo, University of Naples
Lipid rafts – detergent-insoluble membrane microdomains enriched in glycosphingolipids and cholesterol – are thought to be involved in signal transduction and in membrane protein sorting. Species involved in signaling, such as GPI-linked proteins and src kinases, are associated with rafts. But the existence and nature of these structures are controversial, in part because they may be transient. Rafts raise fundamental questions: to what extent does the classic Singer-Nicolson model of the membrane need to be modified to allow for heterogeneity? to what extent is lateral organization of the plasma membrane involved in cell function? The proposed session will examine the nature of rafts, as well as their role in signaling and sorting.
Topics and speakers include:
Rafts in protein sorting. Chair: Chiara Zurzolo
Rafts in signal transduction. Chair: David Holowka
Targeted Proteomics in Cell and Molecular Biology
Completion of the genome project will lead to an even bigger challenge, interpreting the fluxes and flows of material and signals that result in cell behavior. Protein science should play a major role in this endeavor, simply because proteins carry out most of the work in a cell. A new term, proteomics, has been introduced to describe what many expect will be the future of protein structural chemistry. In the present vernacular, the term seems synonymous with attempts to map all proteins in every cell using two-dimensional gels and high-throughput mass spectrometry. But even on a smaller scale, our knowledge of protein-protein, protein-DNA and protein-small molecule interactions is still far from complete. Thus, an immediate task is to find out which proteins bind to what other molecules in the cell, and to examine how the composition of such complexes might shift in response to cellular signals, natural ligands and drugs. This field has been termed targeted proteomics.
Speakers will describe approaches to purify or specifically capture protein complexes on a micro-scale, and how to identify the components by mass spectrometric analysis of fragments. Several experts will then discuss how these discoveries have advanced our understanding of biological systems in their respective fields of interest.
Topics and speakers include:
Supported by an educational grant from the Association of Biomolecular Resource Facilities (ABRF)
Visualizing the Cytoskeleton and Signaling in Mechanically Stimulated Cells
The response of cells to mechanical deformation is now an accepted phenomenon in cell biology as well as biomechanics. In response to applied mechanical load, cells signal using Ca2+, 1P3, cAMP, ATP and other purines, as well as activate components of kinase pathways such as MAPK, JAK/STAT and JNK pathways. Multiple transcription factors can be activated driving specific gene expression dependent on the CRLs in a given promoter. One of the important early/intermediate events in response to strain is a reaction of the existing cytoskeleton to polymerize actin and rearrange cell shape. The focus of this subgroup meeting will be on visualizing signaling events and cytoskeletal changes that occur in response to mechanical load. Emphasis will be placed on cell responses to tension, compression and shear stress-induced cytoskeletal changes, blocking experiments to KO components of the cytoskeleton or signaling pathways and over expression strategies that upregulate proteins involved in a response. Talks will include diverse approaches of load applications, cell types and methods to measure changes in cell expression.
Speakers will include:
Supported by an educational grant from Flexcell Corp.
1999 Minorities Affairs Committee Travel Awards
Lina E. Aguirre, Rutgers University
1999 ASCB Predoctoral Travel Awards
The following students were selected by the ASCB Education Committee to receive travel awards to attend the ASCB Annual Meeting. Membership gifts as well as royalties from Methods in Cell Biology help support these awards. Special congratulations to the top ranked awardees, whose awards are sponsored by the Worthington Biomedical Corporation.
1999 ASCB/Worthington Predoctoral Travel Awardees
1999 ASCB Predoctoral Travel Awardees
A postdoctoral fellowship is available to study cell-based gene therapy of bone, cartilage and tendon. The position is suitable for someone who has recently completed a Ph.D. degree or hopes to graduate this year. Experience in molecular and cell biology, protein analysis and enzyme assays would be a clear advantage. The fellowship is for one year, may be renewed for a second year and will provide opportunities for a career in musculoskeletal research. Investigations will include phage display, genetic reconstitution and cell adhesion assays. For more information contact Gary Balian, Ph.D. Phone: (804) 924-2615, Email, Professor, Departments of Orthopaedic Surgery and Biochemistry & Molecular Genetics. Orthopaedic Research Laboratory, University of Virginia, School of Medicine, Box 374, Charlottesville, VA 22908 or send a c.v. with a brief statement of your research background and the names of three references.
Postdoctoral Research Associate, Scripps Research Institute. Postdoctoral positions are available to participate in a multidisciplinary group studying the dynamics of signaling in living cells. Current projects include 1) Intracellular localization and kinetics of Rho family GTPase activation controlling growth factor/ECM crosstalk 2) Role of Rho family activity and control by upstream regulators in polarized cell movement 3) Role of focal adhesion dynamics in apoptosis induction. Knowledge of GTPase signaling biology, and experience in imaging, protein biochemistry, or molecular biology techniques would be valuable. Please send your curriculum vitae to Dr. Klaus Hahn, Department of Cell Biology, Scripps Research Institute, BCC162, 10550 N. Torrey Pines Rd., La Jolla, California 92037.
University of Colorado at Boulder, Molecular, Cellular, and Developmental Biology. We seek applications from Cell Biologists for a tenure-track faculty position at the Assistant Professor level, beginning in the Fall of 2000. We seek to establish an exceptional program in the area of cell biology. Applications from candidates who would strengthen the Department's diversity are especially encouraged. Complete applications include curriculum vitae, publications, short summary of scientific interests, and three evaluative letters from knowledgeable scientific referees, solicited by the applicant and sent directly to Boulder. All materials must be postmarked by 11/15/99 and sent to: Cell Biology Search, MCD Biology, University of Colorado, Boulder, CO 80309-0347. The University of Colorado at Boulder is committed to diversity and equality in education and employment.
Faculty position in molecular and cellular biology. The Department of Biochemistry at The University of Mississippi Medical Center invites applications for a tenure-track position at any rank. The department is recruiting an applicant who will undertake research on basic mechanisms of disease, utilizing molecular or cellular biology approaches, with special emphasis on cancer. The department is well equipped and has strong research programs in chromatin structure, gene expression, ribosome biogenesis, chromosome replication, nucleic acid biophysics, bioenergetics, enzymology and structural biology. The successful applicant is expected to establish or have an independent, funded research program and to participate in the training of medical, dental and graduate students. Send curriculum vitae, a brief outline of future research plans and the names of three references by January 15, 2000 to: Dr. Mark Olson, Chair, Department of Biochemistry, The University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216-4505. Equal Opportunity Employer, M/F/D/V.
Assistant Professor. The Department of Anatomy, Cell & Neurobiology at the Marshall University School of Medicine is extending the search for a tenure-track position at the Assistant Professor level. This position provides a unique opportunity in a developing program of excellence. The successful candidate will be provided a research laboratory to develop and/or maintain an imaginative, externally funded research program, and will participate in teaching medical and graduate students. A Ph.D. and/or M.D. degree, postdoctoral experience, and a record of publication in quality journals are required. Individuals with an interest and background in anatomical sciences are especially invited to apply. Candidates should send an introductory letter addressing their teaching experience and philosophy, research accomplishments and future research plans, a curriculum vitae, and arrange for at least three letters of reference to: William B. Rhoten, Ph.D., Dept. of Anatomy, Cell and Neurobiology, Marshall University School of Medicine, 1542 Spring Valley Drive, Huntington, WV 25704-9388. Screening of applications will begin October 1, 1999. Marshall University is an EEOC/ADA Employer and especially encourages applications from women and members of minority groups.
Postdoctoral/Research Associate Position in Cell Biology available for developing novel approaches for (1) ex vivo expansion of human megakaryocyte progenitors; (2) apoptosis and megakaryocyte maturation at molecular level; and (3) platelet formation mechanism(s). Expertise in cell culture, immunology, flow cytometry. Send CV and names of three references to: Isaac Cohen, Ph.D., Northwestern University Medical School, Chicago, IL. Fax: 312-238-1815; Email.
Postdoctoral Positions. #1) Developmental study of CNS neurons, sensory ganglion and receptors in co-culture and transplantation experiments; #2) Plastic/regulatory changes in channels and receptors in degeneration and growth of synaptic endings in the CNS. Cell/molecular methods, immuno EM and confocal microscopy, cell culture, patch clamp . Project direction flexible, including transgenic mice; funded for vertebrate auditory system. Competitive salary. Research or Training grant. Contact: DK Morest, UConn Health Center, Farmington, CT 06030.
Cell Signaling Technologies at New England Biolabs Cell/Molecular Biologist: Cell Signaling Technologies (CST), a new company from New England Biolabs, has an opening for a Cell/Molecular Biologist. Minimum requirements include a BS or MS degree in Cell or Molecular Biology. Experience with the use of antibodies and antibody characterization including western blotting, ELISA, immunocytochemistry, and immunoprecipitation techniques is essential. Experience with mammalian tissue culture, transfection, and purification of fusion proteins overexpressed in bacterial and mammalian systems will also be helpful. Excellent verbal and written communication skills are required. CST is located at the NEB facility in Beverly, MA. Send a resume to: Michael Comb, Ph.D., Director, Cell Signaling Technologies, 32 Tozer Road, Beverly, MA 01915. An equal opportunity employer.
|Letters To The Editor|
To the Editor:
The profile of Philip Siekevitz (August, 1999 ASCB Newsletter) was very well done, capturing both the scientist and the delightful intellectual beyond cell biology. But one of the subject's career steps was covered too briefly, namely his seminal role in achieving cell-free protein synthesis in the laboratory of Paul Zamecnik (not Zameenik, as misspelled in the article). Siekevitz was a major player in winning acceptance of cell-free protein synthesis as a valid workbench for molecular biology.
To the Editor:
I enjoyed your interesting and informative profile on Phil Siekevitz. However, I did catch a small error. Dr. Siekevitz was not "the editor of the first cell biology textbook in 1963, called Cell Structure and Function;" he was co-author of this book.
–Ariel G. Loewy
Editor's Note: The coauthors of the three editions of Cell Structure and Function are:
First ed. 1963. Ariel G. Loewy and Philip Siekevitz
To the Editor:
Thank you for the flattering profile on me in the August issue of the ASCB Newsletter. In addition to the correction that my colleague Ariel Loewy has sent you, please note that I sought advice on mitochondrial biochemistry from Fritz Lipmann's lab but did not collaborate with the lab. Also, my lab was the first to use isolated subcellular fractions, such as mitochondria and microsomes, in in vitro protein synthesis.
Stem Cell Policy Challenged
Dear Ms. Marincola:
I am writing as a member of the ASCB to pro-test the ACSB position on stem cell research as reported in the [April 1999] ASCB Newsletter. This position covers an area governed by morality and ethics – issues involving the protection of human life. As such, its enunciation implies its support by the Society, and by extension, by the members of the Society.
In my opinion:
In enunciating this position on human stem cell research, I believe that the ASCB has abdicated its responsibility to provide moral and ethical leadership and is promoting instead an immoral policy.
–Douglas W. Darnowski
Editor's Note: The Council of the ASCB did approve the position as endorsed by 36 Nobel laureates.
The ASCB is grateful to those below who have recently given gifts to support Society activities:
|Grants & Opportunities|
Summer 2000 Research Opportunities in Japan, Korea and Taiwan for U.S. Graduate Students in Science and Engineering. The program provides graduate students in science and engineering first-hand experience in Japanese, Korean and Taiwan research environments, an introduction to the science and science policy infrastructure of the respective countries, and language and cultural training. The programs will last approximately eight weeks from mid-June to August. Applicants must be U.S. citizens or permanent residents; be enrolled at a U.S. institution in a science or engineering Ph.D. program, be enrolled in a M.D. program and have an interest in biomedical research, or be enrolled and completed at least one full academic year in a master's degree program at the end of the calendar year of application; and pursuing studies in fields of science or engineering that are supported by NSF, NIH or USDA, and also are represented among the potential host institutions. International travel costs to and from Japan, Korea or Taiwan, in-country living costs (accommodations, food and professional travel), and an allowance of $2,500 for each participant will be provided. Applications are due by Dec. 1, 1999, to: East Asia and Pacific Program, Room 935, Division of International Programs, National Science Foundation, 4201 Wilson Boulevard, Arlington, VA 22230. For more information email Dr. Christopher Loretz.
|Members In The News|
Phyllis Hanson of Washington University, an ASCB member since 1997, received a new $1 million no-strings grant from the W.M. Keck Foundation.
Y. Peng Loh of the National Institute of Child Health and Human Development of the National Institutes of Health, an ASCB member since 1988, has been named recipient of the 2000 FASEB Excellence in Science Award. Loh has chosen to receive the award at the 2000 ASCB Annual Meeting in San Francisco.
Leonard Hayflick of the University of California, San Francisco, an ASCB member since 1960, was awarded the 1999 Anthony Van Wezel Award from the European Society for Animal Cell Technology.
W. Sue Shafer, Deputy Director of the National Institute of General Medical Sciences of the National Institutes of Health, former Chair of the Women in Cell Biology Committee and an ASCB member since 1976, was appointed to Assistant Vice Chancellor for Research Administration at the University of California, San Francisco.
|ASCB Placement Service|
ASCB Placement Service at the ASCB Annual Meeting in San Francisco
Candidates complete a brief Information Form to register with the Placement Service, and provide times they are available for interviews during the Annual Meeting. Placement Service registrants have access to notebooks of Employer Position Forms, a poster area containing position forms from newly registered employers, and a message center that allows them to send messages to employers and receive messages and individual interview appointments from employers.
Employers complete a brief Employer Position Form for each position they seek to fill. The Employer Reading Room provides access to copies of Candidate Information Forms in notebooks and hanging files (for their personal use) and clerks to schedule interviews. Message files are also available so that employers may receive candidate messages.
Candidate and employer ads will be developed from the registration form for each registrant and will appear in the Placement Service Brochures. A Pre-meeting Brochure, containing ads for candidates and employers who preregister with the ASCB Placement Service, and an On-site Brochure, will be produced at the close of Placement Service registration on Monday and available Tuesday. Brochures are available to Annual Meeting attendees at the Placement Service, the ASCB Booth in the Exhibit Hall, ASCB information tables, and the ASCB National Office headquarters at the Convention Center during the Annual Meeting.
Candidate and employer Placement Service Registration forms may be found on the ASCB website, or may be ordered from the ASCB. Please indicate number of copies required.
ASCB Placement Service Hours
Employer Interview Scheduling
ASCB Placement Service fees remain unchanged:
Preregistration deadline for the ASCB Placement Service is November 5.
|Goodenough, Zheng to Receive WICB Awards|
Ursula Goodenough of Washington University and Yixian Zheng of the Carnegie Institution of Washington have been named to receive the top honors of the ASCB Women in Cell Biology Committee for 1999.
Goodenough, who will receive the WICB Senior Award, was cited for her contributions to cell biology and genetics, to the Society -- she served as President in 1995 and has been a forceful member of the Public Policy Committee -- and as a mentor to other women.
Zheng will receive the Junior Award. She is recognized for outstanding scientific contributions including the successful cloning of microtubule nucleation components from both Xenopus and Drosophila, and forher studies of their expressed, pure proteins and their complexes.
The WICB Awards will be presented at the lunch sponsored by the ASCB WICB and Education Committees on Monday, December 13, at the upcoming ASCB Annual Meeting.
|Alberts Award Recognizes Evolution Defender|
Scott was nominated for her dedication to protecting the teaching of evolution through writing, speeches, media appearances and, importantly, presentations to school boards, teachers, churches and parents.
The teaching of evolution recently suffered a serious setback in the State of Kansas. Evolution defenders and detractors are watching the Kansas decision closely to see if it stands and/or establishes a precedent for other states.
Bruce Alberts, President of the National Academy of Sciences, will present the Award to Scott on Sunday, December 12 at 9:45 a.m. at the 39th ASCB Annual Meeting in Washington.
|Former ASCB President Wins Nobel Prize|
Gunter Blobel of the Rockefeller University, President of the Society in 1989, will receive the 1999 Nobel Prize in Physiology or Medicine.
Blobel was cited for his work in protein signaling, which led to understanding of the molecular roots of many diseases, including primary hyperoxaluria, which causes kidney stones at a young age, as well as some forms of high cholesterol and illnesses such as cystic fibrosis that occur when proteins fail to reach proper positions within the cell.
Blobel, a native of Germany, will receive the prize in Stockholm this December.
|WWW.Cell Biology Education|
The ASCB Education Committee calls attention each month to Web sites of educational interest to the cell biology community. The Committee does not endorse nor guarantee the accuracy of the information at any of the listed sites. If you wish to comment on the selections or suggest future inclusions please send a message to Robert Blystone.
–Robert Blystone for the ASCB Education Committee