NEWSLETTER DECEMBER 2013
CD47 plays a critical role in T-cell recruitment by regulation of LFA-1 and VLA-4 integrin
V. Azcutia, M. Routledge, M. R. Williams, G. Newton, W. A. Frazier, A. Manica, K. J. Croce,
C. A. Parkos, A. B. Schmider, M. V. Turman, R. J. Soberman, and F. W. Luscinskas
CD47 plays an important but incompletely understood role in innate and adaptive immune responses.
CD47 associates in cis with T-cell LFA-1 integrins and regulates expression of high-affinity conformations
of both LFA-1 and VLA-4.
Mol. Biol. Cell 24 (21), 3358–3368
Mammalian target of rapamycin and Rictor control neutrophil chemotaxis by regulating Rac/
Cdc42 activity and the actin cytoskeleton
Yuan He, Dong Li, S. L. Cook, Mee-Sup Yoon, A. Kapoor, C. V. Rao, P. J. A. Kenis, Jie Chen, and Fei Wang
Rictor, a component of mammalian target of rapamycin complex 2 (mTORC2), controls neutrophil
chemotaxis by regulating the dynamics of the actin cytoskeleton via Rac and Cdc42. This function of
Rictor is independent of mTORC2 and the kinase activity of mTOR.
Mol. Biol. Cell 24 (21), 3369–3380
The Editorial Board of
Molecular Biology of the Cell
has highlighted the following articles from the
November 2013 issues. From among the many fine articles in the journal, the Board selects for
these Highlights articles that are of broad interest and significantly advance knowledge or provide
new concepts or approaches that extend our understanding.
A metastatic MDA-MB-231 breast carcinoma cell migrating through a 3D extracellular matrix (ECM)
consisting of type I collagen and Matrigel. The cell expresses TagRFP-cortactin (red) and MT1-MMP-GFP
(green). A reflection of the ECM fibers is shown in blue. Cortactin and MT1-MMP localize to invadopodial
protrusions at the front of the cell (right), which degrade the surrounding matrix. As the cell migrates
through the ECM, a tunnel of degraded matrix is left behind. See Mol. Biol. Cell 24, 1661–1675 for
more details on how
1 integrin regulates invadopodium function in both 2D and 3D matrices. (Image:
Brian T. Beaty, Jose J. Bravo-Cordero, and John Condeelis, Department of Anatomy & Structural Biology,
Albert Einstein College of Medicine)