EMBL Conference: In situ Structural Biology – From Cryo-EM to Integrative Modelling

There is an increasing awareness that mechanistic structural information on molecular machines is ideally generated within the context of intact cells in order to fully grasp how they function in a complex native environment. Recent technological advances have nurtured the development of such in situ structural biology approaches in several disciplines, including cryo-EM, mass spectrometry, super-resolution microscopy, NMR, computational modelling and others.

This conference will bring together experts and early stage researchers from the separate fields

– to provide a platform for structural biology within the cellular context
– to stimulate discussions about how to meaningfully integrate data from different methods
– to define what types of biological questions can already be addressed using in situ structural biology and which might be approached in the future