Walter E. Washington Convention Center
#cellbio2022
Minisymposia
Scientific sessions known as Minisymposia offer the most groundbreaking research representing each of the seven scientific meeting tracks at Cell Bio 2022. Top-scoring abstracts within each scientific track are scheduled into Minisymposium sessions. There are 28 total scientific Minisymposia and one Education Minisymposium.
Minisymposia Sessions and Schedule
Sunday, December 4, 3:30 to 5:00 pm
Track(s): Cellular Dynamics
Room 146C
Co-Chairs: Paulo Caceres, Henry Ford Hospital; and Radha Chauhan, National Centre for Cell Science, Pune
*3:30 pm M7 3D super-resolution fluorescence microscopy maps the variable molecular architecture of the nuclear pore complex. V. Jimenez Sabinina1,2, J. Hossain3, J.-K. Heriche1, P. Hoess1, B. Nijmeijer4, S. Mosalaganti5, M. Kueblbeck1, A. Callegari6, A. Szymborska1, M. Beck7, J. Ries1, J. Ellenberg1; 1European Molecular Biology Laboratory, Heidelberg, Germany, 2current: Bayer AG, Wuppertal, Germany, 3University of Southampton, Southampton, United Kingdom, 4The University of Auckland, Auckland, New Zealand, 5Life Sciences Institute, University of Michigan, Ann Arbor, MI, 6GSK, Heidelberg, Germany, 7Max Plank Institute of Biophysics, Frankfurt, Germany
3:45 pm M8 Analyzing the architecture and function of the Nuclear Pore Complex through targeted degradation. A. Arnaoutov, V. Aksenova, J. Miller, S. Regmi, S. Chen, M. Dasso; Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Bethesda, MD
4:00 pm M9 Insights into the role of Nup62 and Nup93 in assembling cytoplasmic ring and central transport channel of the nuclear pore complex. P. K. Madheshiya1, E. Shukla1, J. Singh1, S. Bawaria1, M. Y. Ansari2, R. Chauhan1; 1National Centre for Cell Science, Pune, India, 2THSTI, Faridabad, India
4:15 pm M10 Chromatin-based membrane remodeling and bilayer lipid metabolism enable spindle disassembly to seal nuclear envelope holes. S. Barger, H. Yang, S. Lee, S. Bahmanyar; Yale University, New Haven, CT
4:30 pm M11 A mechanosensitive checkpoint at the meiotic nuclear envelope revealed by chemically-induced proximity. C. Liu, A. F. Dernburg; University of California, Berkeley/HHMI, Berkeley, CA
4:45 pm M12 The role of O-GlcNAcylation in mRNA nuclear export studied by single-molecule super-resolution microscopy. S. L. Junod, W. Yang; Temple University, Philadelphia, PA
* Vilma Jimenez Sabinina (M7) is the MBoC Paper of the Year Awardee
Track(s): Cellular Dynamics
Room 146B
Co-Chairs: Agathe Chaigne, Utecht University; and Mohan L. Gupta, Iowa State University, Ames
3:30 pm M13 Chromosome size affects alignment efficiency in mammalian mitosis. M. K. Chong, S. Dumont; University of California, San Francisco, San Francisco, CA
3:45 pm M14 Robust mechanism of tension production compensates for increasing the dosage of myosin Myp2 in the cytokinetic contractile ring. J. Martinez-Baird, K. Bellingham-Johnstun, C. Laplante; North Carolina State University, Raleigh, NC
4:00 pm M15 Control of cell proliferation by memories of mitosis. F. Meitinger1,2, R. L. Davis2, M. B. Martinez2, A. K. Shiau2, K. Oegema2,3, A. Desai2,3; 1Okinawa Institute of Science and Technology, Onna, JAPAN, 2Ludwig Institute for Cancer Research, La Jolla, CA, 3University of California San Diego, La Jolla, CA.
4:15 pm M16 Filopodia-mediated morphogenic cytokinesis underlies C. elegans embryonic handedness. Y. Xiong, K. Sugioka; University of British Columbia, Vancouver, BC, Canada
4:30 pm M17 Scaling of chromosome segregation by cytoplasmic flows. O. Afonso, M. Gonzalez-Gaitan; University of Geneva, Geneva, Switzerland
4:45 pm M18 Intracellular enrichment of lipid droplets concentrates tubulin to promote microtubule assembly and chromosome segregation errors. G.-Y. Chen, M. Chung, M. A. Lampson; University of Pennsylvania, Philadelphia, PA
Track(s): Communal Cell
Room 207B
Co-Chairs: Ginger Hunter, Clarkson University; and Stephanie Woo, University of California, Merced
3:30 pm M19 The small GTPase RAB35 coordinates epithelial polarization and cell survival in a human model of epiblast formation. A. Rengarajan, K. Taniguchi; Medical College of Wisconsin, Wauwatosa, WI
3:45 pm M20 An E-cadherin/PAR-3 module links symmetry breaking at cell/cell contacts to tissue-wide polarity in the developing C. elegans intestinal epithelium. V. F. Naturale, M. A. Pickett, J. L. Feldman; Stanford University, Stanford, CA
4:00 pm M21 Self-assembly of cellular neighborhoods converts stochastic signaling into sustained olfactory neurogenesis. S. G. Rajan, J. N. Lombardo, L. M. Nacke, K. Wong, F. Manuchehrfar, J. Liang, A. Saxena; University of Illinois Chicago, Chicago, IL
4:15 pm M22 Investigating Mechanisms of FGF Dispersal and Spatial Organization of Downstream Signaling in Migrating Cells. T. V. Gibney, L. Latifi, A. M. Pani; Biology, University of Virginia, Charlottesville, VA.
4:30 pm M23 Contractile Actomyosin Cables and Pulling Forces from Adjacent Tissue Cooperate to Drive Drosophila Germ-band Extension. T. Zhu, H. Zhu, B. O'Shaughnessy; Chemical Engineering, Columbia University, New York, NY.
4:45 pm M24 A Natural Cell-size Gradient Dictates Patterning of Genome Activation and Vertebrate Early Development. W. Qian1,2, H. Chen1, M. C. Good1,2,3; 1Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 2Cell and Molecular Biology Graduate Program, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 3Department of Bioengineering, School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, PA.
Track(s): Cells in Distress and Disease
Room 201
Co-Chairs: Rochelle K. Nelson, Queensborough Community College; and David Jesse Sanchez, Western University of Health Sciences
3:30 pm M25 Defects Within the HIV-1 Immature Lattice Support Dynamic Remodeling and Protease Dimerization. S. Guo, M. E. Johnson; Johns Hopkins University, Baltimore, MD
3:45 pm M26 Blockade of endo-lysosomal pathway promotes progranulin-deficient microglial toxicity via proinflammatory lipids. K. Hashimoto, E. J. Huang; University of California San Francisco, San Francisco, CA
4:00 pm M27 Immunomodulatory effects of resolvin D2 in a 2-hit infection model. P. Kadiyam Sundarasivarao, J. Walker, A. Rodriguez, B. Spur, K. Yin; Rowan University, Stratford, NJ
4:15 pm M28 Investigating the role of peroxisomes in innate immunity during microbial infection. M. Munawar1,2, S. Leung1, E. Miraglia1,2, P. Kim1,2; 1The Hospital for Sick Children, Toronto, ON, Canada, 2The University of Toronto, Toronto, ON, Canada
4:30 pm M29 SARS-CoV-2 Envelope hijacks an ARFRP1-AP1-AP1AR trans-Golgi network-to-endolysosome trafficking pathway to drive lysosomal deacidification. G. Pearson, M. Broncel, A. Snijders, J. Carlton; Francis Crick Institute, London, United Kingdom
4:45 pm M30 RNase L and other double stranded RNA pathways act together to trigger antiviral gene expression. A. Karasik, H. Lorenzi, N. R. Guydosh; NIH/NIDDK, Bethesda, MD
Track(s): Cellular Dynamics; and Physical Cell
Room 145B
Co-Chairs: Juliet Lee, University of Connecticut; and Jennifer Mitchel, Wesleyan University
3:30 pm M31 Linking Tensed Actin Recognition to Zyxin-Mediated Stress Fiber Repair. D. Y. Z. Phua, X. Sun, G. M. Alushin; The Rockefeller University, New York, NY
3:45 pm M32 Nucleocytoplasmic transport is regulated by forces on the nucleus. K. L. Scott1, P. Purkayastha2, T. P. Lele2,3,4, K. J. Roux1,5; 1Enabling Technologies Group, Sanford Research, Sioux Falls, SD, 2Artie McFerrin Department of Chemical Engineering, Texas A&M University, College Station, TX, 3Department of Biomedical Engineering, Texas A&M Universeity, College Station, TX, 4Department of Translational Medical Sciences, Texas A&M University, Houston, TX, 5Department of Pediatrics, Sanford School of Medicine, University of South Dakota, Sioux Falls, SD.
4:00 pm M33 Actin bundles nucleate pseudo-adhesion signaling scaffolds to sustain cancer cell proliferation. T. Isogai,1, V. S. Murali, N. Venkateswaran, F. Zhou, D. Rajendran, M. Conacci-Sorrell, G. Danuser,1; UTSW Medical Center, Dallas, TX
4:15 pm M34 Cell metabolism regulates contractility. L. D. Troughton, J. R. Beach, P. W. Oakes; Loyola University Chicago, Chicago, IL
4:30 pm M35 Piezo1 and ROCK2 Promote Fast Amoeboid Migration in Confined Environments. A. Caruso, N. Kar, J. Logue; Albany Medical College, Albany, NY
4:45 pm M36 Rap1 coordinates cell-cell adhesion and cytoskeletal reorganization to drive collective cell migration during rapid wound healing. K. E. Rothenberg, R. Fernandez-Gonzalez; University of Toronto, Toronto, ON, Canada
Track(s): Cells in Distress and Disease; and Signaling and Metabolism
Room 202B
Co-Chairs: Quan Zhong; Wright State University; and Jason Lee; Baylor College of Medicine
3:30 pm M37 Peroxisomes maintain mitochondrial redox homeostasis through a novel contact site. L. DiGiovanni1,2, M. Boutry1, P. Khroud1,2, P. Kim1,2; 1The Hospital for Sick Children, Toronto, ON, Canada, 2University of Toronto, Toronto, ON, Canada
3:45 pm M38 Visualizing & dissecting mechanisms driving liquid-crystalline lipid droplet (LD) biogenesis. S. Rogers1, L. Gui1, A. Kovalenko1, V. Zoni2, M. Carpentier3, K. Ramji3, K. Ben Mbarek3, A. Bacle3, P. Fuchs3, P. Campomanes2, E. Reetz1, N. Ortiz Speer1, E. Reynolds1, A. Thiam3, S. Vanni2, D. Nicastro1, M. Henne1; 1UT Southwestern Medical Center, Dallas, TX, 2University of Fribourg, Fribourg, SWITZERLAND, 3Laboratoire de Physique de l’École Normale Supérieure, Paris, FRANCE.
4:00 pm M39 Mitochondrial phospholipids regulate mitochondrial-derived compartment biogenesis. T. Xiao, A. M. English, A. L. Hughes; Department of Biochemistry, School of Medicine, University of Utah, Salt Lake City, UT.
4:15 pm M40 Proteomic profiling identifies distinct mechanisms for the autophagic clearance of nucleoid-enriched mitochondria in Parkinson’s disease. J. Goldsmith1, A. Ordureau2, J. Harper3, E. L. F. Holzbaur1; 1University of Pennsylvania, Philadelphia, PA, 2Memorial Sloan Kettering, New York, NY, 3Harvard Medical School, Cambridge, MA
4:30 pm M41 ER encapsulations of peripherally fragmented mitochondria enhance bioenergetics during infection. W. A. Hofstadter1, K. C. Cook1, E. Tsopurashvili1, R. Gebauer2, J. Park1, E. Quemin2, K. Gruenewald2, I. M. Cristea1; 1Princeton University, Princeton, NJ, 2Universitat Hamburg, Hamburg, Germany
4:45 pm M42 Iron metabolism regulated via DMT1-dependent early endosome-mitochondria interactions is associated with metastatic capacity of invasive breast cancer cells. J. Barra, I. Crosbourne, J. M. Lamar, M. Barroso; Albany Medical College, Albany, NY
Track(s): Signaling and Metabolism; and Cellular Dynamics
Room 207A
Co-Chairs: Farnaz Shamsi, New York University; and Lauren Ragle; The George Washington University
3:30 pm M43 Altering stem cell states by controlling cell signaling information. M. Malleshaiah; Montreal Clinical Research Institute (IRCM), Montreal, QC, Canada
3:45 pm M44 Motoneuron signaling regulates nuclear size scaling and DNA content inDrosophilamuscle fibers. S. E. Windner1, V. E. von Saucken1, P. R. Busch1, A. Manhart2, A. Mogilner3, M. K. Baylies1; 1Memorial Sloan Kettering Cancer Center, New York, NY, 2University College London, London, United Kingdom, 3New York University, New York, NY
4:00 pm M45 Actin-Binding Protein Profilin-1 is an Important Regulator of Vascular-Immune Cell Crosstalk. A. E. A. Gondringer, A. Larregina, P. Roy; University of Pittsburgh, Pittsburgh, PA
4:15 pm M46 Dissecting the role of the cortical actin cytoskeleton in adipose tissue fat storage and cell size determination. R. Ugrankar1, S. Tran1, J. Bowerman2, A. Kovalenko3, B. Paul1, M. Henne1; 1UT Southwestern Medical Center, Dallas, TX, 2Cornell University, Ithaca, NY, 3ETH Zürich, Institute of Biochemistry, Zurich, Switzerland
4:30 pm M47 Cannabinoid Receptor-Mediated Synaptic Signaling and Neural Plasticity in Central Olfactory Neurons. T. Heinbockel, Z.-J. Wang; Howard University College of Medicine, Washington, DC
4:45 pm M48 YAP Promotes an Enhanced Mitogen Signaling State that Supports Cell Proliferation under Quiescence-promoting Cues. K. Ferrick1, T. Meyer2; 1Stanford University, Stanford, CA, 2Weill Cornell Medical College, New York, NY
Sunday, December 4, 5:20 pm to 6:50 pm
Track(s): Education, Professional Development, Diversity and Inclusion
Room 151A
Co-Chairs: Kimberly Baker, University of Indianapolis; Marina Crowder, University of California, Davis; and Kimberly Kandl, St. Olaf College
5:20 pm M1 STEM faculty conceptions of diversity, assessment, grading, and student ability are linked to racial disparities in course grades. N. A. Suarez1, E. S. Park2, M. Wilton3, S. Wang1, S. Brydges1, N. Buswell2, B. K. Sato2, S. M. Lo1; 1University of California San Diego, La Jolla, CA, 2University of California Irvine, Irvine, CA, 3University of California Santa Barbara, Santa Barbara, CA
5:35 pm M2 Using molecular biology preprints to engage undergraduates in the scientific community and enhance their scientific literacy: evidence from a new curriculum on preprint peer review. G. McDowell1, S. Fankhauser2, M. Balgopal3, R. S. Lijek4; 1Lightoller, LLC, Chicago, IL, 2Oxford College, Emory University, Oxford, GA, 3Colorado State University, Fort Collins, CO, 4Mount Holyoke College, South Hadley, MA
5:50 pm M3 Lab Talk as a Mechanism for Course-based Undergraduate Research Experience Effectiveness. M. Plunkett1, K. Subramanian2, C. Zajic1, A. Brotzman1, K. Holliday1, J. Martin1, F. Sarr1, M. Pierce-Tomlin1, E. Wolfson1, K. Zumbro1, J. Olimpo3, E. L. Dolan1; 1University of Georgia, ATHENS, GA, 2University of California, Davis, Davis, CA, 3University of Texas, El Paso, El Paso, TX
6:05 pm M4 An analysis of Course-based Undergraduate Research Experience (CURE) efficacy at community colleges. M. J. Wolyniak1, J. Zhang2, S. DeChenne-Peters3, D. A. Hecht4, M. L. Kuhn5, C. Koletar6, N. Galport6, R. Eddy6, J. J. Provost7, J. K. Bell7, J. E. Bell7; 1Hampden-Sydney College, Hampden-Sydney, VA, 2University of Nebraska, Lincoln, NE, 3Georgia Southern University, Savannah, GA, 4Southwestern College, Chula Vista, CA, 5San Francisco State University, San Francisco, CA, 6Cobblestone Applied Research and Evaluation, Inc., La Verne, CA, 7University of San Diego, San Diego, CA.
6:20 pm M5 Investigating the Relationship Between Metacognitive Awareness and Metacognitive Accuracy in Introductory Biology Students. J. Wollesen, M. Aranda; SOUTHERN ILLINOIS UNIVERSITY EDWARDSVILLE, Edwardsville, IL
6:35 pm M6 Grading in the Biology Classroom: Impacts on Learning, Behavior, and Equity. J. Dyer; Durham Technical Community College, Durham, NC
Track(s): Cells in Distress and Disease; and Cellular Dynamics
Room 202B
Co-Chairs: Anastasia Rosebud Aikins, University of Ghana, Legon; and Kristen C. Johnson; University of New Hampshire-Manchester
5:20 pm M49 Bioinformatic analyses reveal a novel role for Ang-Tie2 signaling in pancreatic cancer-associated fibroblasts. J. C. Gardiner, E. Cukierman; Fox Chase Cancer Center, Philadelphia, PA
5:35 pm M50 Macrophages Promote Tumor Cell Extravasation across an Endothelial Barrier through Thin Membranous Connections. A. Genna, C. Duran, D. Entenberg, J. Condeelis, D. Cox; Albert Einstein College Med-Jack & Pearl Resnick Campus, New York, NY
5:50 pm M51 Nuclear metabolic pathway drives epigenetic rewiring in tumors under nutrient-stress. A. Sawant Dessai1, N. Elhalawany1, E. Katsuta1, C. Prechtl1, B. W. O'Malley2, X. Zhang2, S. Dasgupta1; 1Roswell Park Comprehensive Cancer Center, Buffalo, NY, 2Baylor College of Medicine, Houston, TX
6:05 pm M52 AD80 inhibits aurora kinases and induces mitotic catastrophe and autophagy in pancreatic cancer cells. K. Lima1, L. B. L. de Miranda1, A. D. B. Garnique1, B. O. de Almeida1, M. C. do Nascimento2, G. M. Machado-Santelli1, E. M. Rego2, J. A. Machado-Neto1; 1Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil, 2Faculdade de Medicina, University of São Paulo, São Paulo, Brazil
6:20 pm M53 MLL1 regulates cytokine-driven cell migration and metastasis. P. R. Nair1, L. Danilova1, E. Gómez-de-Mariscal2, D. Kim3, R. Fan3, A. Muñoz-Barrutia2, E. Fertig1, D. Wirtz1; 1Johns Hopkins University, Baltimore, MD, 2Universidad Carlos III de Madrid, Madrid, Spain, 3Yale University, New Haven, CT
6:35 pm M54 Hypusine Signaling Cooperates with SLC3A2 and Fibronectin to Support Cancer Cell Proliferation. C. Geller1, J. Maddela1, R. Tuplano1, R. Güth1, J. Cantor2, J. Kelber1; 1California State Univ-Northridge, Northridge, CA, 2BD Biosciences, San Diego, CA
Track(s): Specialized Cell and Evolution
Room 147A
Co-Chairs: Meng-meng Fu; National Institute of Neurological Disorders and Stroke, NIH; and Le Ma, Thomas Jefferson University
5:20 pm M55 Endocytosis in the axon initial segment maintains neuronal polarity. K. Eichel1, V. Belapurkar2, D. Perrais2, K. Shen1; 1Stanford University, Stanford, CA, 2University of Bordeaux, Bordeaux, France
5:35 pm M56 AP-1 recruits KIF13B to dendrite-selective vesicles at the trans-Golgi network. A. C. Montgomery, M. Bentley; Rensselaer Polytechnic Institute, Troy, NY
5:50 pm M57 Synaptojanin 2-mediated transport of mRNA maintains mitophagy and mitochondrial function in axons and synapses. W. S. Gibbs, PhD, T. L. Schwarz, PhD; Boston Children's Hospital, Boston, MA
6:05 pm MS135 Neuronal activity regulates matrin-3 in a calcium and calmodulin dependent manner. J. Wu, A. Malik, C. Gillies, Q. Doctrove, S. Barmada; University of Michigan, Ann Arbor, MI
6:20 pm M59 TPPP Forms Liquid Condensates and Aggregates in Multiple Systems Atrophy. H. S. Richardson, S. Kemal, J. Nowacki, A. Kopach, M.-m. Fu; National Institute of Neurological Disease and Stroke, Bethesda, MD
6:35 pm M60 Gap junction transendocytosis in glia modifies brain-derived extracellular vesicle formation. L. Udo-Bellner, E. Khodra, S. Khan, R. Stout; New York Institute of Technology College of Osteopathic Medicine, Old Westbury, NY
Track(s): Physical Cell; and Cellular Dynamics
Room 146B
Co-Chairs: Tarun M. Kapoor, The Rockefeller University; and Radhika Subramanian, Harvard Medical School and Massachusetts General Hospital
5:20 pm M61 Investigating the Molecular Mechanism of the Vinculin-Actin Catch Bond and its Role in Vinculin Function and Single Cell Migration. J. Malavade1, V. Chirasani2, M. Khan3, B. Hoffman1, S. Campbell2; 1Duke University BME, Durham, NC, 2University of North Carolina at Chapel Hill, Chapel Hill, NC, 3University of North Carolina at Chapel Hill;, Chapel Hill, NC
5:35 pm M62 Optogenetic activation of microtubule acetylation elucidates its role in actomyosin dynamics and directional cell migration. A. Deb Roy, C. Saez Gonzalez, E. Yadav, F. Shahid, X. Wang, T. Inoue; Johns Hopkins University, Baltimore, MD
5:50 pm M63 Morphological growth dynamics, active microtubule mechanics, and mechanical plasticity of the vertebrate meiotic spindle. T. Fukuyama1, L. Yan2, M. Tanaka3, M. Yamaoka3, K. Saito3, S.-C. Ti4, C.-C. Liao5, K.-C. Hsia5, Y. T. Maeda2, Y. Shimamoto3; 1National Institute of Natural Sciences, Aichi, Japan, 2Kyushu University, Fukuoka, Japan, 3National Institute of Genetics, Shizuoka, Japan, 4The University of Hong Kong, Hong Kong, Hong Kong, 5Academia Sinica, Taipei, Taiwan
6:05 pm M64 Molecular control of actin cortex architecture during cell division. N. Vadnjal1,2, S. Nourreddine3,4, G. Lavoie3, M. Serres1,5, R. Peters2, A. Jégou6, G. Romet-Lemmone6, F. Parmeggiani7, P. Roux3, E. Paluch2; 1University College London, London, United Kingdom, 2University of Cambridge, Cambridge, United Kingdom, 3University of Montreal, Montreal, QC, Canada, 4University of California San Diego, San Diego, CA, 5Institut Pasteur, Paris, France, 6Institut Jacques Monod, Paris, France, 7University of Bristol, Bristol, United Kingdom
6:20 pm M65 Cellular Contractile Structures are Organized by Assembly and Coalescence of Myosin Contractile Units. W.-h. Chou1,1, M. Molaei1,1, H. Wu2, P. Oakes2, J. Beach2, M. Gardel1,1,1,1; 1University of Chicago, Chicago, IL, 2Loyola University Chicago, Chicago, IL
6:35 pm M66 Orientational order: A key feature of focal adhesion molecular architecture and function. V. Grudtsyna1, S. Packirisamy2, T. C. Bidone3, V. Swaminathan2; 1Neils Bohr Institute, Copenhagen, DENMARK, 2Lund University, Lund, SWEDEN, 3University of Utah, Salt Lake City, UT.
Track(s): Cellular Dynamics
Room 146C
Co-Chairs: Kristy Welshhans; University of South Carolina; and Eva Evergren; Queen’s University Belfast
*5:20 pm M67 Regulation of lipid metabolism from the nuclear envelope. S. Lee, H. Merta, J. Carrasquillo Rodríguez, S. Bahmanyar; Yale University, New Haven, CT
5:35 pm M68 Oxysterol-binding protein-related protein 6 regulates peroxisome growth at the peroxisome-ER membrane contact site. D. T. Cheng1,2, A. Lam1,2, R. Hua1, S. Freeman1,2, B. Raught3,2, P. K. Kim1,2; 1Hospital for Sick Children, Toronto, ON, Canada, 2University of Toronto, Toronto, ON, Canada, 3University Health Network, Toronto, ON, Canada
5:50 pm M69 Mechanism of mitochondrial cholesterol import is via an intermembrane space cholesterol shuttle: STAR. P. P. Koganti, A. H. Zhao, M. C. Kern, A. Guo, S. Wasti, V. Selvaraj; Cornell University, Ithaca, NY
6:05 pm M70 APOE Targets Astrocyte Lipid Droplets to Modulate Triglyceride Saturation and Droplet Size. I. Windham, E. D. Wallace, C. Wagner, S. Cohen; University of North Carolina-Chapel Hill, Chapel Hill, NC
6:20 pm M71 Ethanol-induced stress in hepatocytes attenuates lipophagy of nascent lipid droplets at the endoplasmic reticulum surface. R. Schulze1, S. Weller1, E. Krueger1, C. Casey2, M. McNiven1; 1Mayo Clinic, Rochester, MN, 2University of Nebraska Medical Center, Omaha, NE
6:35 pm M72 Rab3 regulates microdomain-mediated plasma membrane recycling. K. R. Levental1, B. Diaz-Rohrer2, I. Castello-Serrano1, H.-Y. Wang1, I. Levental1; 1University of Virginia, Charlottesville, VA, 2University of Texas Health Science Center at Houston, Houston, TX
* Shirin Bahmanyar is the WICB Junior Awardee for Excellence in Research
Track(s): Signaling and Metabolism; and Cells in Distress and Disease
Room 207A
Co-Chairs: Marina Holz, New York Medical College; and Ningning Zhao; University of Arizona
5:20 pm M73 Metabolic Regulation of Autophagy. E. Delorme-Axford1, D. J. Klionsky2; 1Oakland University, Rochester, MI, 2University of Michigan, Ann Arbor, MI
5:35 pm M74 Mitochondrial and lysosomal malfunction involve metabolic rewiring and organelle crosstalk adaptation in mammalian cells and tissues. N. Raimundo; Penn State Univ/Milton S Hershey Medical Ctr, Hershey, PA
5:50 pm M75 The ubiquitin ligase TRIM5αorganizes and activates the upstream mitophagy machinery to maintain mitochondrial homeostasis. B. Saha; University of New Mexico, Albuquerque, NM
6:05 pm M76 p38 MAPK-dependent Phosphorylation of TFEB is Required for Efficient Monocyte to Macrophage Differentiation. J. A. Martina, E. Jeong, R. Puertollano; National Institutes of Health, Bethesda, MD
6:20 pm M77 Mechanistic study for mTORC1-dependent regulation of the lysosomal and autophagic transcription factor TFEB. Z. Cui1, G. Napolitano2, M. E. G. de Araujo3, L. A. Huber3, A. Ballabio2,4, J. H. Hurley1; 1University of California, Berkeley, Berkeley, CA, 2Telethon Institute of Genetics and Medicine (TIGEM), Naples, Italy, 3Medical University of Innsbruck, Innsbruck, Austria, 4Baylor College of Medicine, Houston, TX
6:35 pm M78 Recursive cell membrane macroplatforms drive protein kinase signaling for cell growth. S. Alberti1, V. Relli2, R. Tripaldi2, P. Simeone2, E. Guerra2, A. Sacchetti3, P. Ciufici2, P. Ciufici2, A. Moschella1, V. Caiolfa4, M. Zamai4, M. Trerotola2; 1University of Messina, Messina, ITALY, 2University of Chieti-Pescara, Chieti, ITALY, 3Erasmus University Medical Center, Rotterdam, NETHERLANDS, 4CNIC), Madrid, Madrid, SPAIN.
Track(s): Cellular Dynamics; and Physical Cell
Room 145B
Co-Chairs: Marija Zanic, Vanderbilt University; and Melissa Klein Gardner, University of Minnesota
5:20 pm M79 The mitotic spindle protein CKAP2 regulates microtubule dynamics and ensures faithful chromosome segregation. L. Paim, T. S. McAlear, A. Lopez-Jauregui, S. Bechstedt; Anatomy and Cell Biology, McGill University, Montreal, QC, CANADA.
5:35 pm M80 Role of robust microtubule dynamics in low tension metaphase kinetochore detachment during mitosis. M. Gardner, S. Parmar, S. Mukherjee, S. Gonzalez, D. Wood; University of Minnesota, Minneapolis, MN
5:50 pm M81 The Ndc80-Cdt1-Ska1 complex constitute a minimal processive kinetochore-microtubule coupling unit. M. Chakraborty1, A. Rahi1, S. Agarwal1, K. Vosberg1, S. Agarwal1, A. Wang1, R. McKenney2, D. Varma1; 1Northwestern University Feinberg School of Medicine, Chicago, IL, 2University of California Davis, Davis, CA
6:05 pm M82 Reconstitution of Kinetochore Motility and Microtubule Dynamics Reveals a Role for a Kinesin-8 in Establishing End-on Attachments. J. R. Torvi, J. Wong, D. Serwas, A. Moayed, D. G. Drubin, G. Barnes; University of California, Berkeley, Berkeley, CA
6:20 pm M83 Post-anaphase microtubule networks and interphase microtubules cooperate to re-center the nucleus after spindle breakdown. K. Bellingham-Johnstun, A. Thorn, J. Belmonte, C. Laplante; NCSU, Raleigh, NC
6:35 pm M84 Coupling of microtubule bundles isolates them from local disruptions to set the structural stability of the anaphase spindle. L. Carlini1, F. Renda2, M. Pamula1, A. Khodjakov2, T. Kapoor1; 1Rockefeller University, New York City, NY, 2Wadsworth Center, Albany, NY
Track(s): Communal Cell; and Signaling and Metabolism
Room 207B
Co-Chair. Hans Harn, University of Southern California; and Lindsey Seldin, Emory University
5:20 pm M85 DNA replication establishes asymmetric sister centromere epigenetic. R. Ranjan, X. Chen; Howard Hughes Medical Institute, Baltimore, MD
5:35 pm M86 Immune and Sensory Organ Regeneration Programs Differ in Response to Distinct Types of Cell Death. D. Münch1, N. Denans1, M. E. Swall1,2, M. E. Lush1, T. Piotrowski1; 1Stowers Institute for Medical Research, Kansas City, MO, 2University of Utah, Salt Lake City, UT.
5:50 pm M87 Collective radial intercalation drives epithelial formation in the mammalian axial mesoderm. M. L. Gredler, J. A. Zallen; Sloan Kettering Institute, New York, NY
6:05 pm M88 Golgi organization is a determinant of stem cell signaling in the small intestine. S. Scharaw1, A. Sola Cavajal1, A. Webb1, I. Belevich2, N. Pentinmikko2, S. Das1, E. Jokitalo2, R. Coffey3, P. Katajisto1; 1Karolinska Institute, Solna, Sweden, 2University of Helsinki, Helsinki, Finland, 3Vanderbilt University, Nashville, TN
6:20 pm M89 Muscle cell-derived Ccl8 is a negative regulator of skeletal muscle regeneration. A. Boss-Kennedy, D. Kim, J. Chen; University of Illinois At Urbana–Champaign, Urbana, IL
6:35 pm M90 A wave of NF-κB activity regulates zebrafish scale development. M. Evanitsky, S. Di Talia; Duke University, Durham, NC
Tuesday, December 6, 3:30 to 5:00 pm
Track(s): Communal Cell; and Cellular Dynamics
Room 146C
Co-Chairs: Jennifer M. Gillette, University of New Mexico Health Sciences Center; Terry Lechler; Duke University Medical Center
3:30 pm M91 TEX264 induces reticulophagy in human keratinocytes to drive degradation of the endoplasmic reticulum during epidermal differentiation. C. Johnson, A. Tiwaa, C. L. Simpson; University of Washington, Seattle, WA
3:45 pm M92 Automated serial section electron microscopy and 3D reconstruction reveals role for Nonmuscle Myosin II (NM2) proteins in regulation of organelle structure and cargo transport within the thick ascending limb of the mouse kidney. B. Busselman1, K. Otterpohl1, J. Zimmerman1, M. Mukherjee1, M. Terasaki2, I. Chandrasekar1; 1Sanford Research, Sioux Falls, SD, 2University of Connecticut Health Center, Farmington, CT
4:00 pm M93 Roles for the Planar Cell Polarity Pathway in postnatal intestinal patterning and architecture. R. Lee, K. Sumigray; Yale University, New Haven, CT
4:15 pm M94 A Novel Cby1-like/ciBAR1 Complex Mediates Precise Positioning of the Annulus, a Septin-based Fibrous Ring, Along the Flagellum in Sperm Tail Segmentation. M. Hoque1, J. Chen1, Y. Fuchs2, F.-Q. Li1, K.-i. Takemaru1; 1Stony Brook University, Stony Brook, NY, 2Technion – Israel Institute of Technology, Haifa, Israel
4:30 pm M95 How does the red blood cell lose its nucleus: intrinsic and extrinsic factors regulating erythroid enucleation. L. M. Newton1, C. B. Wölwer1, K. Lim1, E. D. Hawkins2, P. O. Humbert1; 1La Trobe University, Melbourne, Australia, 2The Walter and Eliza Hall Institute, Melbourne, Australia
4:45 pm M96 M6A Epitranscriptome Mediated RNA Stress Gradule Assembly Governs Blood Development and Regeneration. R. Gunage; Boston children's hospital, Boston, MA
Track(s): Physical Cell; and Cellular Dynamics
Room 201
Co-Chairs: Julien Berro, Yale University; and Effie Efthymia, University of Tübingen
3:30 pm M97 Dissecting the Recruitment Kinetics of Mechanosensitive Proteins to Stress Fiber Strain Sites. S. Sala, P. W. Oakes; Loyola University Chicago, Maywood, IL
3:45 pm M98 Mechano- and phospho-regulation of End4p coordinates the temporal and spatial transmission of force during clathrin-mediated endocytosis. Y. Ren1,2, J. Yang1, B. Fujita1,2, Y. Zhang1,1, J. Berro1,2,1; 1Yale University, New Haven, CT, 2Yale University, West haven, CT
4:00 pm M99 Mechanical cues tune the differential localization of LIM domain proteins. S. Seetharaman1, T. Chmiel1, J. Devany1, J. Winkelman1, Y. Fang2, M. Gardel1; 1James Franck Institute, Department of Physics, University of Chicago, Chicago, IL, 2Department of Medicine, Biological Sciences Division, University of Chicago, Chicago, IL.
4:15 pm M100 Coarsening of nuclear condensates is governed by the interplay between chromatin stiffness and condensate intermolecular interaction strength. D. Sankar Banerjee1, T. Chigumira1, J. Kratz1, D. M. Chenoweth2, S. Banerjee1, H. Zhang1; 1Carnegie Mellon University, Pittsburgh, PA, 2University of Pennsylvania, Philadelphia, PA
4:30 pm M101 The role of genome-lamina interactions during cell fate transitions. R. K. Stephens, Y. Miroshnikova; National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD
4:45 pm M102 Membrane compression from exocytosis of synaptic vesicle fusion triggers ultrafast endocytosis. J. Liu1, H. Jing1, S. Raychaudhuri1, T. Ogunmowo1, G. Kusick1, T. Ha1, E. Chapman2, S. Watanabe1; 1Johns Hopkins University, Baltimore, MD, 2University of Wisconsin-Madison, Madison, WI
Track(s): Specialized Cell and Evolution; and Cellular Dynamics
Room 147A
Co-Chairs: Erin Barnhart, Columbia University; and Elva Diaz, University of California, Davis
3:30 pm M103 Evolutionary and functional divergence in the uncoupled microtubule networks of Naegleria. A. S. Kennard1, K. B. Velle1, C. Ballatore2, L. K. Fritz-Laylin1; 1University of Massachusetts, Amherst, Amherst, MA, 2University of California San Diego, La Jolla, CA
3:45 pm M104 The role of a robust cytoskeleton in wound resistance and healing in the ciliate Stentor coeruleus. A. V. Nadkarni1,2, K. S. Zhang1, W. F. Marshall2, S. K. Y. Tang1; 1Stanford University, Stanford, CA, 2University of California San Francisco, San Francisco, CA
4:00 pm M105 Structural cell biology of the invasion organelle from microsporidian parasites. M. Usmani1, N. Coudray1, H. Ramchandani1, M. Kopylov2, D. Bobe2, D. Ekiert1, G. Bhabha1; 1NYU School of Medicine, New York, NY, 2New York Structural Biology Center, New York, NY
4:15 pm M106 A fine structural analysis of visual cortex primary cilia defines anatomical parameters that influence ligand exposure. C. Ott1, R. Torres2, T.-S. Kuan3, A. Kuan4, W. Lee4, N. da Costa2, J. Lippincott-Schwartz1; 1Janelia Research Campus, Ashburn, VA, 2Allen Institute for Brain Science, Seattle, WA, 3University of Albany, Albany, NY, 4Harvard Medical School, Boston, MA
4:30 pm M107 Transgenic-free Live Imaging Reveals the Principles of Cytoskeletal Organization Determining Butterfly and Moth Scale Shape. K. A. DeMarr1, C. Patiño-Descovich2, C. Patiño-Descovich2, R. Null3, J. Kimura4, N. Patel5; 1UC, Berkeley, Berkeley, CA, 2University of North Carolina-Chapel HIll, Chapel Hill, NC, 3Washington University in St. Louis, St. Louis, MO, 4Harvard University, Cambridge, MA, 5Marine Biological Laboratory, Woods Hole, MA
4:45 pm M108 ER network stability promotes organized microtubule disassembly during Compartmentalized Cell Elimination. K. Juanez, M. P. Jones, P. Ghose; University of Texas At Arlington, Arlington, TX
Track(s): Cellular Dynamics
Room 146B
Co-Chairs: Julia D. Romano, Johns Hopkins University; and Richa Sardana, Cornell University
*3:30 pm M109 Structural basis for specific activation of the Rab11 GTPase by the TRAPPII complex. S. Bagde, J. Fromme; Cornell University, Ithaca, NY
3:45 pm M110 Two Model Secretory Cargoes Show Different Kinetics of Golgi Export. F. M. Valbuena, B. S. Glick; The University of Chicago, Chicago, IL
4:00 pm M111 New chemical genetic tools selectively illuminate choline phospholipid distribution in organelle membranes. W. Moore1, R. J. Brea-Fernandez2, N. K. Devaraj1, I. Budin1; 1University of California, San Diego, San Diego, CA, 2Universidade da Coruña, Coruña, Spain
4:15 pm M112 ER-Golgi membrane contact sites control the formation of plasma membrane lipid nanodomains. M. Anwar1, O. Sergeeva1, L. Abrami1, P. Liberali2, G. D'Angelo3, G. van der Goot1; 1Global Health Institute, EPFL, Lausanne, Switzerland, 2Friedrich Miescher Institute, Basel, Switzerland, 3Institute of Bioengineering, EPFL, Lausanne, Switzerland
4:30 pm M113 UHRF1BP1 and UHRF1BP1L (SHIP164) are Chorein Motif Containing Lipid Transport Proteins that Control Membrane Dynamics in the endo-lysosome system. M. G. Hanna1,1,2,1, P. De Camilli1,1,2,1,3; 1Yale University, New Haven, CT, 2Howard Hughes Medical Institute, Chevy Chase, MD, 3Aligning Science Across Parkinson’s (ASAP) Collaborative Research Network, Chevy Chase, MD
4:45 pm M114 Endosomal removal and disposal of dysfunctional, immunostimulatory mitochondrial DNA. L. E. Newman1, N. Tadepalle1, S. Weiser Novak1, C. R. Schiavon1, G. R. Rojas1, J. A. Chevez2, I. Lemersal3, M. Medina4, S. Rocha1, C. G. Towers1, D. A. Grotjahn4, U. Manor1, G. S. Shadel1; 1Salk Institute for Biological Studies, La Jolla, CA, 2University of California, San Diego, La Jolla, CA, 3La Jolla Institute for Immunology, La Jolla, CA, 4The Scripps Research Institute, La Jolla, CA
* Saket Bagde is the graduate student Porter Prize for Excellence in Research awardee.
Track(s): Cells in Distress and Disease; and Signaling and Metabolism
Room 202B
Co-Chairs: Kay F. Macleod, University of Chicago; and Dhanendra Tomar; Wake Forest School of Medicine
3:30 pm M115 Mitochondrial Unfolded Protein Response in Cancer Cell Survival and Growth. D. Chandra; Roswell Park Comprehensive Cancer Center, Buffalo, NY
3:45 pm M116 DLK phosphorylates DRP1 to promote mitochondrial fission and neuronal degeneration after injury. J. Gomez-Deza, M. Nebiyou, A. Slavutsky, C. Le Pichon; National Institutes of Health, Bethesda, MD
4:00 pm M117 Stress-Induced Submitochondrial Protein Translocation Impairs Metabolism. F. Haczeyni1, S. Steensels1, B. D. Stein1, J. M. Jordan1, L. Li2, V. Dartigue1, J. Qiao1, X. K. Zhou1, A. J. Dannenberg1, N. M. Iyengar3,4, H. Yu2, L. C. Cantley1,5, B. A. Ersoy1; 1Weill Cornell Medicine, New York, NY, 2Cornell University, Ithaca, NY, 3Memorial Sloan Kettering Cancer Center, New York, NY, 4Weill Cornell Medical Center, New York, NY, 5Dana Farber Cancer Institute, Boston, MA
4:15 pm M118 Venetoclax resensitizes cells lacking APC expression to paclitaxel treatment. J. Prosperi; IUSM-South Bend/Notre Dame, South Bend, IN
4:30 pm M119 Rho Activation Elevates Glycolysis and Mitochondrial Respiration to Promote a Drug TolerantProliferative Phenotype in Melanoma Cells. V. Siruvallur Murali, D. Rajendran, G. M. Gihana, R. J. DeBerardinis, G. Danuser; UT Southwestern Medical Center, Dallas, TX
4:45 pm M120 Zer Vue. Z. Vue1, L. Vang1, K. Neikirk1,2, A. Hinton Jr1; 1Vanderbilt University, Nashville, TN, 2University of Hawaii at Hilo, Hilo, HI
Track(s): Cellular Genome: 4D Organization, Expression, Replication, and Repair; and Physical Cell
Room 207A
Co-Chair. Daniel R. Larson, National Cancer Institute, NIH; and Chris Toseland, University of Sheffield, United Kingdom
3:30 pm M121 Spatial organisation of mammalian transcription by myosin motors. C. Toseland; University of Sheffield, Sheffield, United Kingdom
3:45 pm M122 Nuclear Position Modulates Long-Range Chromatin Interactions. E. H. Finn1, T. Misteli2; 1Oklahoma Medical Research Foundation, Oklahoma City, OK, 2National Cancer Institute, NIH, Bethesda, MD
4:00 pm M123 Synthetic analysis of chromatin tracing and live-cell imaging indicates pervasive spatial coupling between genes. C. H. Bohrer, D. R. Larson; NIH, Bethesda, MD
4:15 pm M124 TDP-43 represses cryptic exons in transcription machinery to regulate DNA demethylation at neuronal enhancers. S. Hill1, S. Seddighi1, Y. Qi1, W. Wu1, D. Ramos1, J. Reyes1, D. Wang1, E. Callen1, C. Esnault1, R. Dale1, S. Coon1, S. Coon1, M. Prudencio2, M. Prudencio2, L. Petrucelli2, J. Lippincott-Schwartz3, A. Nussenzweig1, M. Ward1; 1National Institutes of Health, Bethesda, MD, 2Mayo Clinic, Jacksonville, FL, 3Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA
4:30 pm M125 Identification of acetylation-independent properties of gene bursting. V. Sood, G. Pegoraro, D. R. Larson, T. Misteli; National Institutes of Health, Bethesda, MD
4:45 pm M126 RNA export through the nuclear pore complex is directional. A. Ashkenazy-Titelman, Y. Shav-Tal, M. Atrash, A. Boocholez, N. Kinor; Bar-Ilan University, Ramat Gan, Israel
Track(s): Cellular Dynamics; and Communal Cell
Room 145B
Co-Chairs: . Magali Suzanne, Centre de Biologie Integrative; and Yanlan Mao; University College London
3:30 pm M127 Protrusion growth driven by myosin-generated force. G. N. Fitz, M. L. Weck, C. Bodnya, O. L. Perkins, M. J. Tyska; Vanderbilt University, NASHVILLE, TN
3:45 pm M128 Actin cortex drives membrane tension propagation in cells. H. De Belly1, S. Yan2, H. Borja da Rocha3, S. Ichbiah3, J. Town1, H. Turlier3, C. Bustamante2, O. Weiner1; 1UCSF, San Francisco, CA, 2UC Berkeley, Berkeley, CA, 3College de France, Paris, France
4:00 pm M129 Different Types of Direct Talin-Actin Binding Play Specific Roles in Cell-ECM Adhesion During Mammalian Development. W. Deng1, R. Carr1, A. Haage2, M. Pavlova3, P. Roca-Cusachs3, G. Tanentzapf1; 1University of British Columbia, Vancouver, BC, Canada, 2University of North Dakota, Grand Forks, ND, 3University of Barcelona, Barcelona, Spain
4:15 pm M130 Nuclei as mechanical bumpers during epithelial remodeling. N. de Leeuw, R. Budhathoki, T. Blankenship, D. Loerke; University of Denver, Denver, CO
4:30 pm M131 Understanding how actomyosin dynamics drive apical constriction. P. Zhang, B. Goldstein; UNC At Chapel Hill, Chapel Hill, NC.
4:45 pm M132 The PI 4-kinase Four wheel drive promotes cell surface expansion during apical constriction-mediated tissue folding. W. Chen, V. Bergstein, B. He; Dartmouth College, Hanover, NH
Tuesday, December 6, 5:20 pm to 6:50 pm
Track(s): Cellular Dynamics
Room 146C
Co-Chairs: Jennifer Zenker, ARMI, Monash University; David K. Breslow, Yale University
*5:20 pm M133 Understanding how and why RNAs localize to centrosomes. J. Fang1, H. Zein-Sabatto1, P. V. Ryder1,2, D. A. Lerit1; 1Emory University School of Medicine, Atlanta, GA, 2Wandrer, Inc., Atlanta, GA
5:35 pm M134 Building order from disorder: mechanistic and regulatory roles for phase condensation in the assembly of microtubule architectures by Tubulin polymerization-promoting protein. C.-C. CHANG, S. M. Coyle; The University of Wisconsin-madison, Madison, WI
5:50 pm M135 The Pre-procentriole is a Molecular Condensate Initiated by Sas4 Phase Separation. J. M. Ryniawec, G. C. Rogers; University of Arizona, Tucson, AZ
6:05 pm M136 Control of actomyosin contractility by spectrin maintains the distribution of axonal microtubules and F-actin. G. L. Swaim, O. Glomb, S. Yogev; Yale University, New Haven, CT
6:20 pm M137 Vertebrate model to study cilia assembly and repair. V. G. Rao, S. Redeman, S. Kulkarni; Cell and development Biology, UNIVERITY OF VIRGINIA, CHARLOTTESVILLE, VA.
6:35 pm M138 Probing Mechanical and Functional Contributions of F-actin to Microtubule Aster Organization in Cycling Xenopus Egg Extract. L. Bai, C. M. Field, T. J. Mitchison; Department of Systems Biology, Harvard Medical School, Boston, MA.
* Dorothy Lerit is the 2022 Blobel Early Career awardee.
Track(s): Cellular Genome: 4D Organization, Expression, Replication, and Repair
Room 207B
Co-chairs: Viji M. Draviam; Queen Mary University of London; Mary Dasso, National Institute of Child Health and Human Development, NIH
5:20 pm M139 Sexually dimorphic regulation of meiotic recombination by the C. elegans synaptonemal complex proteins. C. Cahoon, C. Richter, A. Dayton, D. Libuda; University of Oregon, Eugene, OR
5:35 pm M140 G2/M synchronization with CDK1 inhibitor suppresses genome-wide mutations and genome rearrangements during genome editing. K. Kondo, N. Fukuda, K. Soga, S. Yoshiba, J. Narushima, N. Shibata, C. Taguchi, K. Sakata, R. Kato; National Institute of Health Sciences, Kawasaki, Japan
5:50 pm M141 Naturally occurring variants in human chromosome segregation genes reveal novel Chromosomal Instability aiding Variant (CIVa) in kinetochore-microtubule bridges. A. Islam, C. Manjarrez, X. Song, T. Gore, V. Draviam; Queen Mary University of London, London, United Kingdom
6:05 pm M142 Reorganisationof Centromere Chromatin During the G2-Mitosis Transition Requires Condensin. K. Samejima1, C. A. Brackley2, N. Gilbert3, D. Marenduzzo4, W. C. Earnshaw1; 1Wellcome Centre for Cell Biology, University of Edinburgh, Edinburgh, United Kingdom, 2School of Physics and Anatomy, University of Edinburgh, Edinburgh, United Kingdom, 3IGMM, University of Edinburgh, Edinburgh, United Kingdom, 4School of Phyics and Astronomy, University of Edinburgh, Edinburgh, United Kingdom
6:20 pm M143 Centromere Innovations within a Mouse Species. N. Pandey1, C. Gambogi1, J. Dawicki-McKenna1, U. Arora2,3, G. Logsdon4, J. Ma5, P. Lamelza5, M. Lampson5, B. Dumont2,3, B. Black1; 1Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 2The Jackson Laboratory, 600 Main Street, Bar Harbor, ME, 3Tufts University, Boston, MA, 4University of Washington School of Medicine, Seattle, WA, 5School of Arts and Sciences, University of Pennsylvania, Philadelphia, PA
6:35 pm M144 The SUN-family protein Sad1 interacts with the histone H2A-H2B dimer to mediate the spatial organization of heterochromatin through phase separation. Q. Dong1, W. Sun2, J. Gao1, Y. Chen3, F. Li1; 1Department of Biology, New York University, New York, NY, 2Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences,, Shanghai, China, 3Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, China
Track(s): Physical Cell
Room 201
Co-Chairs: Shambaditya Saha, Institute of Molecular Biotechnology (IMBA), Vienna; and Adam J. Engler, University of California, San Diego
*5:20 pm M145 OpenCell: engineering solutions to map the intracellular proteome. M. D. Leonetti; Chan Zuckerberg Biohub, San Francisco, CA
5:35 pm M146 Interpreting geometric rules of early kidney formation for synthetic morphogenesis. J. Viola, J. Liu, L. Prahl, A. Huang, T. Chan, G. Hayward-Lara, C. Porter, A. Hughes; University of Pennsylvania, Philadelphia, PA
5:50 pm M147 Engineering Platforms for Visualizing Mechanical Regulation of the Actin Cytoskeleton. J. Levin, A. Pan, G. M. Alushin; The Rockefeller University, New York, NY
6:05 pm M148 New Tools to Raise pH in Living Cells and Study pH-dependent Cell Polarization and Migration. C. E. T. Donahue, K. Trull, C. Troll, L. Gile, K. A. White; University of Notre Dame, South Bend, IN
6:20 pm M149 Coupling between Membrane Protein Condensates and Ordered Membrane Domains. H. Wang1, S. Chan1, S. Dey1, I. Castello-Serrano1, J. Ditlev2, M. Rosen3, K. Levental1, I. Levental1; 1University of Virginia, Charlottesville, VA, 2University of Toronto, Toronto, ON, Canada, 3University of Texas Southwestern Medical Center, Dallas, TX
6:35 pm M150 Measurement of Mechanical Strain on Lamin A/C and Vimentin Intermediate Filaments using FRET-force Biosensors. B. E. Danielsson1, B. G. Abraham2, E. Mäntylä2, D. E. Conway3, T. O. Ihalainen2; 1Virginia Commonwealth University, Richmond, VA, 2Tampere University, Tampere, Finland, 3Ohio State University, Columbus, OH
* Manuel Leonetti (M145) is the 2022 Innovation in Research Awardee
Track(s): Cells in Distress and Disease; and Cellular Dynamics
Room 202B
Co-Chairs: Guillaume Thibault, Nanyang Technological University, Singapore; and Kuo-Hui Su; University of Toledo
5:20 pm M151 Rab7-positive late endosomes show rapid responses to lysosomal membrane permeabilization. R. Mulligan, B. Winckler; University of Virginia, Charlottesville, VA
5:35 pm M152 The selective autophagy receptor p62 and the heat shock protein HSP27 facilitate lysophagy via the formation of phase-separated condensates. E. Gallagher, E. Holzbaur; University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA
5:50 pm M153 Altered secretory trafficking and processing of amyloid precursor protein variants associated with familial Alzheimer's disease. J. Wang, L. Fourriere, P. A. Gleeson; Bio21 Institute, University of Melbourne, Melbourne, Australia
6:05 pm M154 Macroautophagy and Aging Synergize to Drive Dysfunctional Metabolism in the Alveolar Epithelium of Non-Resolving Lung Fibrosis. L. R. Rodriguez, J. Katzen, A. Murthy, Y. Tomer, T. Dimopoulos, S. Iyer, K. Chavez, V. Abraham, M. F. Beers; University of Pennsylvania, Philadelphia, PA.
6:20 pm M155 SQST-1/p62 and SKN-1/Nrf2 promote Compartmentalized Cell Elimination under stress. Y. Mohamed, A. Elkhalil, P. Ghose; University of Texas at Arlington, Arlington, TX
6:35 pm M156 LRRK2 kinase activity regulates GCase activity, glycosphingolipids and BMP in preclinical models and human subjects of PD. M. T. Maloney1, X. Wang1, R. Ghosh1, S. Andrews1, V. Bondar1, O. Davis1, J. Chen1, A.-N. Ho1, S. Masoud1, H. Nguyen1, A. Arguello1, J. De Vicente1, R. Maciuca1, J. Suh1, S. Davis1, M. L. Reyzer2, S. Zhu3, M. Deen3, D. Vocadlo3, S. Huntwork-Rodriguez1, A. G. Henry1; 1Denali Therapeutics, South San Francisco, CA, 2Vanderbilt University, Nashville, TN, 3Simon Fraser University, Vancouver, BC, Canada
Track(s): Signaling and Metabolism
Room 207A
Co-Chairs: Mohit Kumar Jolly, Indian Institute of Science; and Jeremiah Keyes; Pennsylvania State University Erie, Magee Womens Research Institute Allied Member
5:20 pm M157 Uncovering Hyperglycemia-induced mRNA Translation Control in Pancreatic Beta Cells. A. Cheruiyot, J. E. Schaffer; Joslin Diabetes Center, Boston, MA
5:35 pm M158 The Target of Rapamycin TORC2 complex regulates the activity of conserved NDR kinase Orb6 to control cell morphogenesis and chronological lifespan. D. D'Urso, L. Doyle, C. Romero, C. Chen, F. Verde; University of Miami, Miami, FL
5:50 pm M159 The ubiquitin ligase HUWE1 potentiates WNT/β-catenin signaling through a mechanism mediated by APC, AXIN1 and GSK3A/B that is independent from the control of CTNNB1 stability. J. K. McKenna, Y. Wu, P. Sonkusre, A. M. Lebensohn; National Cancer Institute, National Institutes of Health, Bethesda, MD
6:05 pm M160 C9orf72/SMCR-8 negatively regulates C. elegans EGFR signaling via the Arf6 GTPase. A. Sabbir, A. Sobhani, S. Deng, K. Gauthier, C. Rocheleau; Research Institute of the McGill University Health Centre, Montreal, QC, Canada
6:20 pm M161 New View on Information Processing with pH Dynamics Regulating Transcription Factor-DNA Binding Selectivity. K. Kisor, D. L. Barber; University of California, San Francisco, San Francisco, CA
6:35 pm M162 pYtags: a biosensing strategy to monitor receptor tyrosine kinase signaling in living cells. P. Farahani1, X. Yang2, E. Mesev1, K. Fomby1, C. Bashor2, C. Nelson1, J. Toettcher1; 1Princeton University, Princeton, NJ, 2Rice University, Houston, TX
Track(s): Cellular Dynamics; and Communal Cell
Room 146B
Co-Chairs: Minna Roh-Johnson, University of Utah; Charlotte M. Vines, University of Texas-El Paso
5:20 pm M163 The Role of the mDia Formins in Breast Cancer Invasion. A. Ramirez; Albert Einstein College of Medicine, Bronx, NY
5:35 pm M164 Regulation of focal adhesions during single cell migration in vivo. Q. Xue, S. Varady, T. Waddell, J. Carrington, M. Roh-Johnson; University of Utah, Salt Lake City, UT
5:50 pm M165 A Local Ca2+ and RhoA Signaling Crosstalk Facilitates Cell Migration by Reinforcing Actin Network in the Lamellipodia. E. Iu1, A. Bogatch1, W. Deng2, J. Humphries3, M. Humphries4, G. Tanentzapf2, S. Plotnikov1; 1University of Toronto, Toronto, ON, Canada, 2University of British Columbia, Vancouver, BC, Canada, 3Manchester Metropolitan University, Manchester, United Kingdom, 4University of Manchester, Manchester, United Kingdom
6:05 pm M166 A novel role for non-muscle myosin IIA during neutrophil interstitial migration in live animal. N. Melis1, D. Chen1, B. Subramanian2, C. Bleck3, W. Losert4, C. Parent5, R. Weigert1; 1CCR - NCI - NIH, Bethesda, MD, 2Lineberger Comprehensive Cancer Center, Chapel Hill, NC, 3NHLBI - NIH, Bethesda, MD, 4University of Maryland, College Park, MD, 5University of Michigan, Ann Arbor, MI
6:20 pm M167 Two Distinct F-Actin Force-Generating Modules Coordinate Membrane Remodeling During Membrane Trafficking in Live Mice. M. Heydecker1, A. Masedunskas2, S. Ebrahim1, M. Appaduray2, A. Shitara1, N. Bryce2, P. Gunning2, E. Hardeman2, R. Weigert1; 1Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, 2School of Medical Sciences, University of New South Wales, Sydney, Australia
6:35 pm M168 Secretion of DNA and nuclear envelope-derived exosomes from the back of actively migrating neutrophils. S. B. Arya1,2, S. P. Collie3, C. A. Parent1,2,4; 1Department of Pharmacology, University of Michigan, Ann Arbor, MI, 2Life Sciences Institute, Ann Arbor, MI, 3Cellular and Molecular Biology Graduate Program, University of Michigan, Ann Arbor, MI, 4Department of Cell and Developmental Biology, Ann Arbor, MI.
Track(s): Cellular Dynamics; and Specialized Cell and Evolution
Room 145B
Co-Chairs: Swapneeta Date, Vanderbilt University; and Christian E. Rocheleau; McGill University
5:20 pm M169 Endoplasmic reticulum and peroxisomes hitchhike on motile endosomes. S. Abeling, A. Morrissey, B. Driscoll, E. Wagner, J. Salogiannis; Larner College of Medicine At the University of Vermont, Burlington, VT
5:35 pm M170 Scaffolding proteins JIP3 and JIP4 activate microtubule-based transport in a GTPase-dependent fashion. S. E. Cason,1,1, E. L. F. Holzbaur,1; University of Pennsylvania, Philadelphia, PA
5:50 pm M171 INF2 Regulates Organelle Motility via ER-associated Actin. C. R. Schiavon1, Y. Wang1, A. Manole1, T.-C. Sung1, Y. Dayn1, P. Latour2, A. Echaniz-Laguna3, M. E. Shy4, B. J. Zuchero5, G. S. Shadel1, U. Manor1; 1Salk Institute for Biological Studies, La Jolla, CA, 2Hospices Civils de Lyon, Bron, France, 3Paris-Sud University, Le Kremlin Bicêtre, France, 4University of Iowa, Iowa City, IA, 5Stanford University, Stanford, CA
6:05 pm M172 SNX17-dependent endocytic recycling is critical for synaptic function and plasticity. P. Rivero-Rios, T. Tsukahara, A. Chen, G. Chavis, S. Giridharan, S. Iwase, M. Sutton, L. Weisman; University of Michigan, Ann Arbor, MI
6:20 pm M173 Functions of ER structure and ER-endosome contacts at synapses. M. Quiñones-Frías, A. Rodal; Brandeis University, Waltham, MA
6:35 pm M174 Non-degradative Ubiquitin Signals are the Key Regulators of COPI-mediated ER-Golgi Homeostasis. S. S. Date, 1, T. R. Graham; Vanderbilt University, Nashville, TN
Congratulations to the 2022 Minisymposia Co-Chairs!
Minisymposium Co-Chairs are responsible for scoring submitted abstracts, selecting talks for Minisymposia sessions from top-scoring abstracts, and introducing the speakers on the day of the Minisymposium. Please note co-chairs, or members of their labs, are only eligible to present a talk within their Minisymposium if they are in the top-scoring abstracts after the concealed review. There is not a reserved or guaranteed speaking slot for co-chairs, or members of their lab.
A minimum of four (4) and a maximum of ten (20) Minisymposium Co-Chairs will be selected per scientific meeting track, depending on the popularity of the track.
Minisymposium Co-Chairs will:
- Read and score up to 150 abstracts submitted to their scientific track. The abstracts will have author information concealed to reduce bias in scoring. The review period will take place between August 4 and August 18.
- Create a specified number of Minisymposia sessions, varying from two to 10 sessions depending on the track. Each Minisymposium session will consist of six (6) talks selected from top-scoring abstracts.
- Chair the session at Cell Bio 2022 in Washington, DC. Two Co-Chairs will work together to introduce the speakers in each Minisymposium, keep speakers on time, and moderate the live Q&A following each talk.
Diversity and Inclusion
ASCB is committed to ensuring that a diversified and inclusive program is presented to our attendees. Minisymposia Co-Chairs will be required to ensure talks selected are from presenters with diverse ethnic backgrounds, gender, research backgrounds, career-levels, geographic location.
Availability Requirements
Minisymposium Co-Chairs must be available during the following time periods
- Thursday, August 4 through Thursday, August 18 - Concealed Abstract Scoring Review Period
- Tuesday, August 23 through Tuesday, August 30- Formation of Minisymposia sessions with talk selections from top-scoring abstracts.
- Sunday, December 3 and Tuesday, December 5- Minisymposia sessions will be scheduled from approximately 3:40 pm to 5:10 pm and 5:40 pm to 7:10 pm on both Sunday, December 3 and Tuesday, December 5. You will need to be available for any of the four time slots.
Co-Chair Benefits
Minisymposia Co-Chairs will receive:
- Complimentary registration to the meeting.
- Stipend toward travel.
- Co-Chairs based in North America will receive a $300 travel stipend.
- Co-Chairs based internationally outside of North America will receive a $500 travel stipend.
Timeline & Key Dates
| Co-Chair Applications | Applications accepted to co-chair a Minisymposium. | Deadline: April 27 |
| Co-Chair Review | Program Committee Track Chairs review and score applications. | Late April to Late May |
| Co-Chair Notifications | Applicants are notified. | Late May/Early June |
| Abstract Submission | Abstracts accepted for consideration for Minisymposium Talks. There are 6 talks in each Minisymposium. | Opens Early June; Closes August 2 |
| Abstract Review | Minisymposia Co-Chairs review and score the abstracts and the weighted average score is used determine top-scoring abstracts in each scientific track. | August 4 to August 18 |
| Session Scheduling | Co-Chairs use top-scoring abstracts to create Minisymposia sessions. | August 23 to August 30 |
| Speaker Notification | Abstract submitters are notified. Co-Chairs also receive correspondence about their session. | By September 15 |