December 2-16
#cellbio2020
Minisymposia
Minisymposia sessions offer the most groundbreaking research representing each of the seven scientific meeting tracks at Cell Bio Virtual 2020. Top-scoring abstracts submitted to each scientific track by the July 30 deadline have been scheduled into Minisymposium sessions.
There are be 28 total scientific Minisymposia and one Education Minisymposium at the Cell Bio Virtual 2020 meeting. Click here for the list of Minisymposia co-chairs. See below for full details on each session.
Minisymposia Sessions and Schedule
Wednesday, December 2, 10:00 am to 11:30 am EST
Track(s): Education and Professional Development
Co-Chairs: Stephanie Levi Blumer, Department of Biology, Oakton Community College, and Le Paliulis, Department of Cell Biology and Biochemistry, Bucknell University
10:00 am EM1 The social context of STEM education. B. M. Dewsbury; University of Rhode Island, Kingston, RI.
10:15 am EM2 Faculty conceptions of diversity in higher education. N. A. Suarez1, S. Wang1, S. Brydges2, S. M. Lo3; 1Mathematics and Science Education, University of California San Diego, La Jolla, CA, 2Chemistry and Biochemistry, University of California San Diego, La Jolla, CA, 3Cell and Developmental Biology, University of California San Diego, La Jolla, CA.
10:30 am EM3 Examining the Intersection of Equity, Trauma-Informed Pedagogy, & STEM Education. M. Imad; Pima Community College, Tucson, AZ.
10:45 am EM4 Student buy-in toward and utilization of in-person and online formative assessments. B. A. Couch, K. R. Brazeal, L. A. Wheeler; University of Nebraska-Lincoln, Lincoln, NE.
11:00 am EM5 Empirical insights into the negative mentoring experiences of life science doctoral students. T. T. Tuma1, J. D. Adams2, B. C. Hultquist3, E. L. Dolan2; 1Plant Biology, University of Georgia, Athens, GA, 2Biochemistry & Molecular Biology, University of Georgia, Athens, GA, 3University of Georgia, Athens, GA.
11:15 am EM6 The Genomics Education Partnership: Genuine undergraduate research experiences for online courses. M. Van Stry1, W. Leung2, K. Sandlin3, L. K. Reed4; 1Lane College, Jackson, TN, 2Washington University in St. Louis, St. Louis, MO, 3University of Alabama, Tusaloosa, AL, 4University of Alabama, Tuscaloosa, AL.
Monday, December 7, 11:30 am to 1:00 pm EST
Track(s): Specialized Cell and Evolution: Neurobiology, Immunology, and Emerging Model Systems and Cellular Dynamics: Compartmentalization, Trafficking, Cytoskeleton, Division, and Migration
Co-Chairs: Elva Diaz, University of California, Davis, and Maxwell G. Heiman, Harvard Medical School, Boston Children's Hospital
11:30 am M1 Synaptic active zone assembly requires scaffold molecule phase separation. N. McDonald1, R. Fetter2, K. Shen1; 1Stanford University, Stanford, CA, 2Howard Hughes Medical Institute, Stanford, CA.
11:45 am M2 Zebrafish NADPH oxidase 2 regulates retinal ganglion cell guidance downstream of slit2/robo2. A. Terzi, H. Roeder, C. J. Weaver, D. M. Suter; Biological Sciences, Purdue University, West Lafayette, IN.
12:00 pm M3 Astrocyte signaling restricts motor dendrite dynamicity to a critical period of plasticity. S. D. Ackerman1, N. A. Perez-Catalan1, M. R. Freeman2, C. Q. Doe1,3; 1Institute of Neuroscience, University of Oregon, Eugene, OR, 2Vollum Institute, Oregon Health and Science University, Portland, OR, 3Howard Hughes Medical Institute, Chevy Chase, MD.
12:15 pm M4 Genomic instability drives the neurodevelopmental and neuroinflammation defects due to RibonucleaseH2 loss in mice. A. Aditi, P. Schreiner, S. Downing, Y. Kwak, Y. Li, H. R. Russell, T. Shaw, P. J. McKinnon; St. Jude Children's Research Hospital, Memphis, TN.
12:30 pm M5 Identification of extrinsic cues promoting target-selective axon regeneration. L. Walker, C. Guevara, M. Granato; University of Pennsylvania, Philadelphia, PA.
12:45 pm M6 Genetic Disruption of the WASH Complex Drives Endo-lysosomal Dysfunction and Cognitive-Movement Impairments in Mice and Humans. J. L. Courtland1, T. W. A. Bradshaw1, G. Waitt2, E. J. Soderblom2, T. Ho2, A. Rajab3, R. Vancini4, I. Kim5, S. H. Soderling6; 1Neurobiology, Duke University School of Medicine, Durham, NC, 2Proteomics and Metabolomics Shared Resource, Duke University School of Medicine, Durham, NC, 3Burjeel Hospital, VPS Healthcare, Muscat, OMAN, 4Pathology, Duke University School of Medicine, Durham, NC, 5Anatomy and Neurobiology, University of Tennessee Health Science Center, Memphis, TN, 6Cell Biology, Duke University School of Medicine, Durham, NC.
Track(s): Signaling and Metabolism: Integrating Intra- and Intercellular Signaling, and Information Processing, and Cells in Distress and Disease: Cancer, Aging, Infection, Stress, Chemical Biology, and Therapeutics
Co-Chairs: Jose Javier Bravo-Cordero, Medicine, Division of Hematology and Oncology, The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, and Jeanette Gowen Cook, Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill
11:30 am M7 Network-imaging of cellular transitions between proliferative and Non-proliferative states. O. Argüello-Miranda, 2015, J. Noh; Lyda Hill department of Bioinformatics, University of Texas Southwestern Medical Center, Dallas, TX.
11:45 am M8 Contact Inhibition in Mother Cells Shifts an Activator-Inhibitor Balance to Direct Newborn Cells to Quiescence . Y. Fan, T. Meyer; Stanford University, Stanford, CA.
12:00 pm M9 Single-cell measurements of cyclin-dependent kinase activity in C. elegans. M. A. Q. Martinez, T. N. Medwig-Kinney, D. Q. Matus; Biochemistry and Cell Biology, Stony Brook University, Stony Brook, NY.
12:15 pm M10 An expanded topology of the human cell cycle. W. Stallaert; University of North Carolina at Chapel Hill, Chapel Hill, NC.
12:30 pm M11 The bistable, biphasic regulation of PP2A-B55 accounts for the dynamics of mitotic substrate phosphorylation. J. Kamenz1,2, L. Gelens3, J. Ferrell, Jr.2,4; 1Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Groningen, NETHERLANDS, 2Department of Chemical and Systems Biology, Stanford University, Stanford, CA, 3Department of Cellular and Molecular Medicine, KU Leuven, Leuven, BELGIUM, 4Department of Biochemistry, Stanford University, Stanford, CA.
12:45 pm M12 Regulation of the oxidative stress response via dynamic regulation of p53 and MAPK activity. R. Hanson, E. Batchelor; Department of Integrative Physiology and Biology, University of Minnesota, Minneapolis, MN.
Track(s): Cellular Dynamics: Compartmentalization, Trafficking, Cytoskeleton, Division, and Migration, and Physical Cell: Bioengineering, Mechanobiology, and Synthetic Biology
Co-Chairs: Mira Krendel, Dept. Cell and Developmental Biology, SUNY Upstate Medical University, and Andrei Smertenko, Washington State University
11:30 am M13 FLN-1/Filamin is required to organize the cytoskeleton, organelles, and promote cortical stability in a contractile tissue. C. Kelley, E. Cram; Biology, Northeastern University, Boston, MA.
11:45 am M14 Dynamics of clathrin-mediated endocytosis and actin in the native tissue context. M. Mund, A. Picco, M. Kaksonen; University of Geneva, Geneva, SWITZERLAND.
12:00 pm M15 +TIP-dependent Tuning of MicrotubuleMechanical Flexibility Protects Cells Navigating Confined Environments. R. J. Ju1, K. M. Dean2, R. Fiolka3, M. Nobis4, P. Timpson4, G. Danuser3, N. K. Haass5, S. J. Stehbens1; 1Institute for Molecular Bioscience, University of Queensland, Brisbane, AUSTRALIA, 2Department of Cell Biology, University of Texas Southwestern Medical Center, Brisbane, TX, 3Department of Cell Biology, Department of Bioinformatics, University of Texas Southwestern Medical Center, Dallas, TX, 4The Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Cancer Division, University of New South Wales, Sydney, AUSTRALIA, 5Diamantina Institute, University of Queensland, Brisbane, AUSTRALIA.
12:15 pm M16 A Non-Centrosomal Microtubule-Organizing Center with Unique Architecture and Gamma-Tubulin-Independent Microtubule Assembly Mechanisms in Adipose Cells. T. L. Megraw1, Y. Zheng2, C. Zheng1, J. V. Chen3, R. A. Buchwalter1, E. M. Wight1, M. M. L. Tillery1; 1Biomedical Sciences, Florida State University, Tallahassee, FL, 2Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, 3Molecular, Cellular, and Developmental Biology, University of California at Santa Barbara, Santa Barbara, CA.
12:30 pm M17 Kinesin-4 Motor Teams Effectively Navigate Dendritic MT Arrays Through Track Switching and Regulation of MT Dynamics. E. M. Masucci1,2,3, P. K. Relich3, A. E. Ghiretti3, M. Lakadamyali2,3, E. M. Ostap2,3, E. L. Holzbaur2,3; 1Graduate Group in Biochemistry and Molecular Biophysics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, 2Pennsylvania Muscle Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, 3Department of Physiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
12:45 pm M18 Cytoplasm properties limit cytoskeleton dynamics. A. T. Molines, 11, C. Edrington2, J. Lemiere1, A. Serra-Marques1, L. Holt3, G. Goshima4, G. Brouhard2, F. Chang1; 1Cell & Tissue Biology, UCSF, San Francisco, CA, 2Life Sciences, McGill University, Montréal, QC, CANADA, 3NYU, New-York, NY, 4Biological Science, Nagoya university, Nagoya, JAPAN.
Track(s): Cells in Distress and Disease: Cancer, Aging, Infection, Stress, Chemical Biology, and Therapeutics, and Cellular Dynamics: Compartmentalization, Trafficking, Cytoskeleton, Division, and Migration
Co-Chairs: Meng C.Wang, Department of Molecular and Human Genetics and Huffington Center on Aging, Baylor College of Medicine/HHMI, and Anjana Saxena, Biology Department, Brooklyn College, and Biology/Biochemistry Programs, Graduate Center (CUNY)
11:30 am M19 Caging the nucleus: Lamins and LINC complex proteins facilitate microtubular organization around myonuclei. N. M. Shaw, M. R. Ketterer, L. L. Wallrath; Department of Biochemistry, University of Iowa, Iowa City, IA.
11:45 am M20 Chemical intervention of influenza virus mRNA nuclear export. M. Esparza1, A. Mor1, H. Niederstrasser2, K. White3, A. White1, K. Zhang1, S. Gao1, J. Wang1, J. Liang2, S. Sho1, R. Sakthivel1, A. A. Sathe4, C. Xing4, R. Munoz-Moreno3, J. W. Shay1, A. Garcia-Sastre5, J. Ready2, B. Posner2, B. M. A. Fontoura1; 1Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX, 2Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX, 3Icahn School of Medicine at Mount Sinai, New York, NY, 4University of Texas Southwestern Medical Center, Dallas, TX, 5Icahn School of Medicine, New York, NY.
12:00 pm M21 Structure of the C9orf72 complex haploinsufficient in ALS/FTD. M. Su, S. A. Fromm, R. Zoncu, J. H. Hurley; Department of Molecular and Cell Biology and California Institute for Quantitative Biosciences, University of California, Berkeley, Berkeley, CA.
12:15 pm M22 An intrinsically disordered, glycine-rich protein governs mycobacterial actin-based motility. N. S. Hill, M. D. Welch; Molecular Cell Biology, University of California, Berkeley, Berkeley, CA.
12:30 pm M23 Defining Mechanisms Underlying Virus Regulation of Mitochondrial Bioenergetics During Infection. C. N. Betsinger, J. D. Federspiel, C. S. R. Jankowski, W. A. Hofstadter, C. J. Otter, P. M. Jean Beltran, I. M. Cristea; Princeton University, Princeton, NJ.
12:45 pm M24 ZeroCostDL4Mic: an open platform to simplify, access and use Deep-Learning in Microscopy. R. F. Laine1,2, L. von Chamier1, G. Jacquemet3,4, R. Henriques1,2; 1MRC-LMCB, UCL, London, UNITED KINGDOM, 2The Francis Crick institute, London, UNITED KINGDOM, 3Turku Bioscience Centre, University of Turku, Turku, FINLAND, 4Faculty of Science and Engineering, Åbo Akademi University, Turku, FINLAND.
Track(s): Physical Cell: Bioengineering, Mechanobiology, and Synthetic Biology, and Communal Cell: Development, Differentiation, Regeneration, Stem Cells, Organs, and Organoids
Co-Chairs: Amit Pathak, Department of Mechanical Engineering & Materials Science Washington University in St. Louis, and Assaf Zaritsky, Department of Software and Information Systems Engineering, Ben-Gurion University of the Negev, Israel
11:30 am M25 Local, heterogeneous regions of active RhoA drive asymmetric junction contraction. K. Cavanaugh1, T. Chmiel1, M. Staddon2, S. Budnar3, A. Yap3, E. Munro1, S. Banerjee4, M. Gardel1; 1University of Chicago, Chicago, IL, 2University College London, London, UNITED KINGDOM, 3The University of Queensland, Brisbane, AUSTRALIA, 4Carnegie Mellon University, Pittsburgh, PA.
11:45 am M26 The nature of mitotic forces in epithelial monolayers. V. K. Gupta1, S. Nam1,2,3, J. Camuglia4, J. L. Martin5, E. N. Sanders5, L. E. O'Brien5, A. C. Martin4, T. Kim6, O. Chaudhuri1; 1Department of Mechanical Engineering, Stanford University, Stanford, CA, 2Wyss Institute for Biologically Inspired Engineering, Cambridge, MA, 3Harvard John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, 4Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, 5Department of Molecular and Cellular Physiology, Stanford University, Stanford, CA, 6Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN.
12:00 pm M27 Trans-epithelial Fluid Pumping Performance of Renal Epithelial Cells and Mechanics of Cystic Expansion. I. Choudhury1, Y. Li2, P. Mistriotis3, E. Dixon4, A. C. N. Vasconcelos1, D. Maity1, M. Benson1, R. Walker4, F. Qian4, K. Konstantopoulos1, O. Woodward4, S. Sun1; 1Johns Hopkins University, Baltimore, MD, 2Kennesaw State University, Atlanta, GA, 3Auburn University, Auburn, AL, 4University of Maryland, Baltimore, MD.
12:15 pm M28 Calcium signaling contributes to epithelial tight junction remodeling during cell shape changes. S. Varadarajan1, R. E. Stephenson1, I. S. Erofeev2, A. B. Goryachev2, A. L. Miller1; 1Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI, 2Centre for Synthetic and Systems Biology, University of Edinburgh, Edinburgh, UNITED KINGDOM.
12:30 pm M29 Mechanical Priming Regulates Future Invasion of Epithelial Cells through Collagen Remodeling. J. A. Almeida1, Y. Lee1, C. Walter2, J. Mathur2, B. Sarker2, A. Pathak2; 1Biomedical Engineering, Washington University in St. Louis, St.Louis, MO, 2Mechanical Engineering, Washington University in St. Louis, St.Louis, MO.
12:45 pm M30 α-catenin regulates cell junction fluidity by cooperative mechanosensing. M. Sergides1, C. Arbore2, L. Gardini3, F. S. Pavone2, M. Capitanio2; 1University of Cyprus, Nicosia, CYPRUS, 2University of Florence, Firenze, ITALY, 3CNR-INO, Firenze, ITALY.
Track(s): Physical Cell: Bioengineering, Mechanobiology, and Synthetic Biology, and Cellular Genome: 4D Organization, Expression, Replication, and Repair
Co-Chairs: Dennis E. Discher, University of Pennsylvania, and Yasushi Okada, Laboratory for Cell Polarity Regulation, Center for Biosystems Dynamics Research, RIKEN, Japan
11:30 am M31 Coordination of RNA abundance with cell size. S. Berry, M. Müller, L. Pelkmans; University of Zurich, Zurich, SWITZERLAND.
11:45 am M32 Fat Droplets Have High Interfacial Tension and are Sufficiently Rigid to Deform and Rupture the Nucleus. I. L. Ivanovska, M. Tobin, L. Dooling, D. E. Discher; University of Pennsylvania, Philadelphia, PA.
12:00 pm M33 HP1α is a chromatin crosslinker that dictates nuclear and mitotic chromosome mechanics, morphology, and function. A. Strom1, R. J. Biggs2, E. J. Banigan3, X. Wang4, C. Herman5, J. Collado2, F. Yue4, J. Ritland6, D. Scalzo6, M. Groudine6, C. P. Brangwynne1, J. Marko2, A. D. Stephens7; 1Princeton University, Princeton, NJ, 2Northwestern University, Evanston, IL, 3Massachusetts Institute of Technology, Cambridge, MA, 4Northwestern University, Chicago, IL, 5Northwestern University, AmherstEvanston, IL, 6The Fred Hutchinson Cancer Research Center, Seattle, WA, 7University of Massachusetts Amherst, Amherst, MA.
12:15 pm M34 Modulation of single cell volume and mass growth by intrinsic and extrinsic factors. N. Srivastava1, L. Calabrese2, M. Cosentino-lagomarsino2, M. Piel1; 1Institut Curie, Paris, FRANCE, 2IFOM, Milan, ITALY.
12:30 pm M35 Size-dependent increase in RNA Polymerase II initiation rates mediates gene expression scaling with cell size. X. Sun1, A. Bowman2, M. Priestman1, F. Bertaux2, A. Martinez-Segura1, W. Tang2, C. Whilding1, D. Dormann1, V. Shahrezaei2, S. Marguerat1; 1MRC London Institute of Medical Sciences, London, UNITED KINGDOM, 2Department of Mathematics, Imperial College London, London, UNITED KINGDOM.
12:45 pm M36 Vascular Smooth Muscle Cell Phenotype is Regulated by lncRNA Heterogeneous Expression. J. Mayner1, A. Kumar1, P. Beri1, A. Torkamani2, K. Baldwin2, A. Engler1; 1Bioengineering, UCSD, San Diego, CA, 2The Scripps Research Institute, San Diego, CA.
Track(s): Cells in Distress and Disease: Cancer, Aging, Infection, Stress, Chemical Biology, and Therapeutics, and Cellular Dynamics: Compartmentalization, Trafficking, Cytoskeleton, Division, and Migration
Co-Chairs: Raphael Gaudin, CNRS – University of Montpellier, France, and Kamena Kostova, Department of Embryology, Carnegie Institution for Science
11:30 am M37 Mitochondria health and deterioration under nutrient stress are dependent on lipid trafficking pathways setup and controlled by vacuolar phase-separated microdomains. A. Seo, J. Lippincott-Schwartz; HHMI-Janelia Research Campus, Ashburn, VA.
11:45 am M38 The Role of Calnexin in Regulating Proteostasis of RESET Substrates. A. M. Cheatham, N. Sharma, S. Abhishek, P. Satpute-Krishnan; Molecular Biology and Biochemistry, UniforMedical Services University, Bethesda, MD.
12:00 pm M39 ZNF574 is a quality control factor monitoring ribosome biogenesis. J. Akers, M. Makurak, C. Jung, K. Kostova; Embryology, Carnegie Inst Washington, Baltimore, MD.
12:15 pm M40 Distinct regions of Chlamydia trachomatis effector protein IncE interact with components of retromer and endosome vesicle fusion machinery. K. Pha1, C. Elwell1, E. McMahon1, J. Sherry1, T. Solvik2, C. Tran1, A. Frando3, K. Mirrashidi1, N. Krogan4, D. Swaney4, J. Engel1; 1Medicine, UCSF, San Francisco, CA, 2Pathology, UCSF, San Francisco, CA, 3University of Washington, Seattle, WA, 4Cellular and Molecular Pharmacology, UCSF, San Francisco, CA.
12:30 pm M41 Controlling intracellular transport to tune cell-based (immuno)-therapies. Z. Gouveia1, S. Divoux2, A. Buffière2, G. Boncompain2, F. Perez2; 1Institut Curie & Honing Biosciences, Paris, FRANCE, 2Cell Biology and Cancer, Institut Curie, Paris, FRANCE.
12:45 pm M42 Cell migration in the very fast lane. J. Kehrer1, R. Douglas1, D. Klug1, C. Moreau1, S. Olberg2, K. Quadt1, J. Ripp1, J. Sattler1, B. Spreng1, J. P. Spatz3, U. S. Schwarz4, F. Frischknecht1; 1Center of Infectious Diseases, Parasitology, University of Heidelberg Medical School, Heidelberg, GERMANY, 2Center of Infectious Diseases, IDIP, University of Heidelberg Medical School, Heidelberg, GERMANY, 3Max Planck Institut, Stuttgart, GERMANY, 4Theoretical Physics, University of Heidelberg, Heidelberg, GERMANY.
Tuesday, December 8, 11:30 am to 1:00 pm EST
Track(s): Cellular Dynamics: Compartmentalization, Trafficking, Cytoskeleton, Division, and Migration, and Specialized Cell and Evolution: Neurobiology, Immunology, and Emerging Model Systems
Co-Chairs: Peter W. Baas, Department of Neurobiology and Anatomy and Graduate Program in Neuroscience, Drexel University College of Medicine, and Le Ma, Department of Neuroscience, Thomas Jefferson University
11:30 am M43 Microtubule polymerisation is required for microtubule bundle organisation in axons and coordinated by GSK-3β. A. Voelzmann1, J. Parkin1, P. Slater2, L. Lowery3, N. Sanchez Soriano4, A. Prokop1, I. Hahn1; 1Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UNITED KINGDOM, 2Department of Biology, Boston College, Boston, MA, 3Department of Medicine, Boston University Medical Center, Boston, MA, 4Institute of Translational Medicine, University of Liverpool, Liverpool, UNITED KINGDOM.
11:45 am M44 Significance of Minus-end-out Microtubules in Dendrites. P. Thyagarajan, C. Feng, M. Rolls; Pennsylvania State University, University Park, PA.
12:00 pm M45 Activation of cytoplasmic dynein through microtubule crossbridging. M. Chakraborty, A. Toleikis, N. Siddiqui, R. Cross, A. Straube; Centre for Mechanochemical Cell Biology, University of Warwick, UNITED KINGDOM.
12:15 pm M46 Doublecortin contributes to neuronal morphogenesis by stabilizing the growth cone microtubule network. R. Charafeddine, T. Wittmann; University of California, San Francisco, San Francisco, CA.
12:30 pm M47 Understanding the role of microtubule-associated protein 9 (MAP9) in C. elegans ciliated neurons. M. Tran; Stanford University, Stanford, CA.
12:45 pm M48 ATAXIN-2 is an essential regulator of cytoskeletal dynamics in Drosophila neurons. R. Norkett, U. del Castillo, V. I. Gelfand; Northwestern University, Chicago, IL.
Track(s): Cells in Distress and Disease: Cancer, Aging, Infection, Stress, Chemical Biology, and Therapeutics, and Signaling and Metabolism: Integrating Intra- and Intercellular Signaling, and Information Processing
Co-Chairs: Jerry Edward Chipuk, Icahn School of Medicine at Mount Sinai, and Sophia HL George, Department of Obstetrics, Gynecology and Reproductive Sciences, Division of Gynecologic Oncology, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine
11:30 am M49 Histone H3.3 mutations that drive pediatric gliomagenesis suppress both epigenetic regulation and mitotic phosphorylation of the pericentromere. C. A. Day1, K. T. Vaughan2, J. Robinson1, E. H. Hinchcliffe1; 1Masonic Cancer Center, University of Minnesota-Hormel Inst, Austin, MN, 2Biological Science, University of Notre Dame, Notre Dame, IN.
11:45 am M50 Regulation of MLK3 and JNK during ovarian cancer cell cycle progression. L. Cedeño-Rosario, D. Honda, W. R. Taylor, D. N. Chadee; Department of Biological Sciences, The University of Toledo, Toledo, OH.
12:00 pm M51 Lateral macrophage mitochondrial transfer functions as a signaling source in cancer cells. C. U. Kidwell, J. Casalini, J. S. Johnson, M. Roh-Johnson; Biochemistry, University of Utah, Salt Lake City, UT.
12:15 pm M52 Inactivation of the Hippo Tumor Suppressor Pathway Promotes Melanomagenesis. M. Vittoria1, N. Kingston2, E. Xia3, S. McDonald3, X. Varelas2, N. Ganem1; 1Pharmacology, Boston University School of Medicine, Boston, MA, 2Biochemistry, Boston University School of Medicine, Boston, MA, 3Boston University School of Medicine, Boston, MA.
12:30 pm M53 Notch signaling contributes to proliferation of glioma cells via the regulation of Hexokinase2. S. Kuwabara, J. Ma, M. Itoh; Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, JAPAN.
12:45 pm M54 N-Myristoyltransferase-1 is necessary for lysosomal degradation and mTORC1 activation in cancer cells. Y. Chen1, M. Navarrete2, Y. Wang3, N. C. McClintock4, R. Sakurai3, F. Wang3, K. T. Chen4, T. Chou3, V. Rehan3, D. J. Lee2, B. Diaz1; 1Medical Hematology and Oncology, The Lundquist Institute At Harbor-UCLA Medical Center, Torrance, CA, 2Dermatology, The Lundquist Institute At Harbor-UCLA Medical Center, Torrance, CA, 3Pediatrics, The Lundquist Institute At Harbor-UCLA Medical Center, Torrance, CA, 4Surgery, Harbor-UCLA Medical Center, Torrance, CA.
Track(s): Communal Cell: Development, Differentiation, Regeneration, Stem Cells, Organs, and Organoids
Co-Chairs: Xiaonan Han, Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Cincinnati Children's Hospital Medical Center (CCHMC), and Bo Wang, Department of Bioengineering, Stanford University
11:30 am M55 BioID network propagation identifies the TWIST1-dependent chromatin regulatory module directing cranial neural crest migration and specification. X. Fan, P. Masamsetti, J. Sun, K. Engholm-Keller, P. Osteil, J. Studdert, M. Graham, N. Fossat, P. Tam; Children’s Medical Research Institute, The University of Sydney, Syndey, AUSTRALIA.
11:45 am M56 The mitophagy receptor NIX drives DRP1-dependent mitochondrial fragmentation to promote epidermal differentiation. C. L. Simpson1, M. K. Tokito2, R. Uppala3, M. K. Sarkar3, J. E. Gudjonsson3, E. L. F. Holzbaur2; 1Dermatology, University of Pennsylvania, Philadelphia, PA, 2Physiology, University of Pennsylvania, Philadelphia, PA, 3Dermatology, University of Michigan, Ann Arbor, MI.
12:00 pm M57 Genetic chimerism causes regeneration defects in the planarian. C. Chai1, J. Gibson1, H. Vu2, M. Khariton1, J. Rink2, B. Wang1,3; 1Department of Bioengineering, Stanford University, Stanford, CA, 2Department of Tissue Dynamics and Regeneration, Max Planck Institute for Biophysical Chemistry, Göttingen, GERMANY, 3Department of Developmental Biology, Stanford University, Stanford, CA.
12:15 pm M58 A Spatial Gradient of Cell Size Regulates Genome Activation and Vertebrate Early Development. W. Qian1, H. Chen1, M. C. Good1,2; 1Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, PA, 2Department of Bioengineering, University of Pennsylvania, Philadelphia, PA.
12:30 pm M59 Mapping the complex paracrine response to hormones in the human breast at single-cell resolution. L. Murrow, Z. Gartner; University of California San Francisco, San Francisco, CA.
12:45 pm M60 Development and function of circadian rhythms in human intestinal organoids. A. Rosselot1, M. Park1, T. Matsu-Ura1, G. Wu2, D. Flores2, K. Subramanian1, S. Lee1, N. Sundaram2, T. Broda2, H. McCauley2, J. Hawkins2, K. Chetal2, N. Salomonis2, N. Shroyer3, M. Helmrath2, J. Wells2, J. Hogenesch2, S. Moore4, C. Hong1; 1Pharmacology & Systems Physiology, University of Cincinnati, Cincinnati, OH, 2Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 3Baylor College of Medicine, Houston, TX, 4University of Virginia, Charlottesville, VA.
Track(s): Cellular Dynamics: Compartmentalization, Trafficking, Cytoskeleton, Division, and Migration
Co-Chairs: Pierre Gönczy, Swiss Federal Institute of Technology Lausanne (EPFL), Switzerland, and Tim Stearns, Department of Biology, Stanford University
11:30 am M61 A newly identified primary cilium mechanically controls meiotic chromosomal pairing and germ cell morphogenesis in zebrafish and mouse. A. Mytils, V. Kumar, R. Deis, K. Levy, F. Nather, Y. M. Elkouby; Developmental Biology and Cancer Research, The Hebrew University of Jerusalem Faculty of Medicine, Jerusalem, ISRAEL.
11:45 am M62 Dancing basal bodies: basal bodies bend in response to ciliary force. A. Junker1, A. Soh1, E. O'Toole2, L. Woodhams3, P. Bayly3, C. Pearson1; 1University of Colorado, Anschutz Medical Campus, Aurora, CO, 2University of Colorado, Boulder, CO, 3Washington University, Saint Louis, MO.
12:00 pm M63 Arp2/3-dependent functions in ciliary assembly and beyond in Chlamydomonas. P. Avasthi1,2, B. M. Bigge1,2; 1Department of Biochemistry & Cell Biology, Geisel School of Medicine At Dartmouth, Hanover, NH, 2Department of Anatomy & Cell Biology, University of Kansas Medical Center, Kansas City, KS.
12:15 pm M64 MTOC function at the centrosome and the ciliary base is driven by specific PCM protein. J. Magescas, M. V. Tran, S. Eskinazi, J. L. Feldman; Stanford University, Stanford, CA.
12:30 pm M65 Co-movement of astral microtubules, organelles and F-actin suggests aster positioning by surface forces in frog eggs. J. F. Pelletier1,2,3, C. M. Field1,2, S. Fürthauer4, T. J. Mitchison1,2; 1Department of Systems Biology, Harvard Medical School, Boston, MA, 2Marine Biological Laboratory, Woods Hole, MA, 3Department of Physics, Massachusetts Institute of Technology, Cambridge, MA, 4Center for Computational Biology, Flatiron Institute, New York, NY.
12:45 pm M66 The post-transcriptional regulations of centrosomal plp mRNA in Drosophila. J. Fang, D. Lerit; Emory University School of Medicine, Atlanta, GA
Track(s): Signaling and Metabolism: Integrating Intra- and Intercellular Signaling, and Information Processing, and Cellular Dynamics: Compartmentalization, Trafficking, Cytoskeleton, Division, and Migration
Co-Chairs: Mike Henne, Department of Cell Biology, UT Southwestern Medical Center, and Ina Sonnen, Hubrecht Institute, the Netherlands
11:30 am M67 Altered tryptophan metabolism in growth and proliferation. M. Conacci-Sorrell; UT Southwestern medical center, Dallas, TX.
11:45 am M68 Spatial Organization of Hexokinase 1 via O-GlcNAcylation. H. Wang1, J. Vant2, S. Yu1, S. Yoon1, A. Singharoy2, G. Pekkurnaz1; 1University of California San Diego, La Jolla, CA, 2Arizona State University, Tempe, AZ.
12:00 pm M69 Seipin traps triacylglycerols in the ER to facilitate their nanoscale phase separation. V. T. Salo, X. Prasanna, S. Li, K. Ven, H. Vihinen, E. Jokitalo, I. Vattulainen, E. Ikonen; University of Helsinki, Helsinki, FINLAND.
12:15 pm M70 Structural mechanism for amino acid-dependent Rag GTPase nucleotide state switching by SLC38A9. S. A. Fromm1, R. E. Lawrence2,3, J. H. Hurley1,4; 1University of California, Berkeley, CA, 2Howard Hughes Medical Institute, Chevy Chase, MD, 3University of California at San Francisco, San Francisco, CA, 4Lawrence Berkeley National Laboratory, Berkeley, CA.
12:30 pm M71 Spatial and Temporal Regulation of Sensors of a Mitogen Activated Protein Kinase Pathway Contribute to a Pathway-Specific Response. A. Prabhakar, B. Gonzalez, H. Dionne, S. Basu, A. Pitoniak, P. J. Cullen; Biological Sciences, University at Buffalo, Buffalo, NY.
12:45 pm M72 Spatial heterogeneities in cortical mechanics control mitotic spindle positioning. M. Kelkar1, P. Bohec1, M. Smith2, B. Baum1, G. Salbreux2, G. Charras1; 1University College London, London, UNITED KINGDOM, 2Francis Crick Institute, London, UNITED KINGDOM.
Track(s): Cellular Dynamics: Compartmentalization, Trafficking, Cytoskeleton, Division, and Migration, and Cellular Genome: 4D Organization, Expression, Replication, and Repair
Co-Chairs: Megan C. King, Department of Cell Biology, Yale School of Medicine, and Carolyn M. Phillips, University of Southern California
11:30 am M73 Drosophila Wash and the Wash regulatory complex function in nuclear envelope budding. K. A. Davidson, J. M. Verboon, M. Nakamura, S. M. Parkhurst; Fred Hutchinson Cancer Research Ctr, Seattle, WA.
11:45 am M74 Atg39 Drives Remodeling of Inner and Outer Nuclear Membranes to Selectively Capture Nuclear Cargo for Autophagy. S. Chandra, P. Mannino, D. Thaller, N. Ader, T. Melia, P. Lusk; Yale School of Medicine, New Haven, CT.
12:00 pm M75 Traip suppresses chromosome bridges via a mitotic DNA repair mechanism to control brain size. R. S. O'Neill, C. J. Fagerstrom, N. M. Rusan; Cell and Developmental Biology Center, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD.
12:15 pm M76 Central-spindle microtubules are strongly coupled to chromosomes during both anaphase A and anaphase B. C. Yu1, S. Redemann2, H. Wu3, R. Kiewisz4, T. Yoo5, W. Conway3, R. Farhadifar6, T. Müller-Reichert4, D. Needleman3; 1University of California, Santa Barbara, Santa Barbara, CA, 2University of Virginia, Charlottesville, VA, 3Harvard University, Cambridge, MA, 4Technische Universität Dresden, Dresden, GERMANY, 5Harvard Medical School, Boston, MA, 6Simons Foundation, New York, NY.
12:30 pm M77 Rewiring quality control in C.elegans meiosis using a new chemically-induced proximity system. C. Liu1, A. Dernburg2; 1University of California, Berkeley, Berkeley, CA, 2University of California, Berkeley/HHMI, Berkeley, CA.
12:45 pm M78 pre-rRNAs contribute to chromosome periphery protein recruitment and affect chromosome congression. F. Cisneros Soberanis, M. Carmena, E. Peat, W. C. Earnshaw; Wellcome Centre for Cell Biology, Edinburgh, UNITED KINGDOM.
Track(s): Physical Cell: Bioengineering, Mechanobiology, and Synthetic Biology, and Cellular Dynamics: Compartmentalization, Trafficking, Cytoskeleton, Division, and Migration
Co-Chairs: Elizabeth Haswell, Washington University in St. Louis, and Geraldine Margaret O'Neill, Children's Cancer Research Unit, The Children's Hospital at Westmead and Faculty of Medicine and Health, The University of Sydney, Australia
11:30 am M79 Synergistic Phase Separation of Two Pathways Promotes Integrin Clustering and Focal Adhesion Formation. L. Case, L. Henry, M. Rosen; UT Southwestern Medical School, Dallas, TX.
11:45 am M80 Contractile Cytoplasmic Fragments Exhibit ROCK-dependent Oscillatory Motion. A. Padhi1, D. S. Alabduljabbar2, R. K. Kapania3, A. S. Nain1; 1Mechanical Engineering, Virginia Tech, Blacksburg, VA, 2Biomedical Engineering, University of California Davis, Davis, CA, 3Aerospace and Ocean Engineering, Virginia Tech, Blacksburg, VA.
12:00 pm M81 The nuclear piston generates migration paths in confining microenvironments. F. Alisafaei1, H. Lee2, K. Adebawale2, O. Chaudhuri3, V. Shenoy1; 1University of Pennsylvania, Philadelphia, PA, 2Stanford University, Palo Alto, CA, 3Stanford University, Palo Alto, PA.
12:15 pm M82 Actomyosin-Dependent Force Generation is Hijacked to Promote Tumor Progression via ECM Remodeling and Immunosuppression. Y. Chen, W. Jung, S. Park, J. Chen; Johns Hopkins University, Baltimore, MD.
12:30 pm M83 Matrix rigidity controls epithelial-mesenchymal plasticity and tumor metastasis via a mechanoresponsive EPHA2/LYN complex. L. Fattet1, M. Matsumoto2, B. Aubol1, A. Kumar1, J. Adams1, A. Chen1, R. Sah1, A. Engler1, E. Pasquale2, J. Yang1; 1University of California, San Diego, La Jolla, CA, 2Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA.
12:45 pm M84 SCHEEPDOG: challenges and new approaches to using electrotaxis as a tool to program directed cell migration. T. Zajdel, G. Shim, D. Cohen; Princeton University, Princeton, NJ.
Thursday, December 10, 11:30 am to 1:00 pm EST
Track(s): Cellular Dynamics: Compartmentalization, Trafficking, Cytoskeleton, Division, and Migration, and Physical Cell: Bioengineering, Mechanobiology, and Synthetic Biology
Co-Chairs: Weihong Qiu, Department of Physics, Oregon State University, and Radhika Subramanian, Harvard Medical School and MGH
11:30 am M85 Probing the molecular organization of cells and organelles using cryo-electron microscopy. D. Nicastro, T. Heuser, J. Lin, K. Song, C. Berciu, G. Fu, Z. Shang, X. Zhao, L. Gui, N. Phan, X. Lou, E. Reetz, K. Cai, Y. Zhao, J. Pinskey; Department of Cell Biology, UT Southwestern Medical Center, Dallas, TX.
11:45 am M86 Microtubule dynamics and force production examined with multi-scale computational modeling and electron cryotomography. N. Gudimchuk1,2,3, E. V. Ulyanov1, D. Vinogradov2, V. V. Alexandrova2, V. A. Fedorov4,2, I. B. Kovalenko4,5,2, E. O'Toole6, F. I. Ataullakhanov1,2,3, J. R. McIntosh6; 1Physics, Lomonosov Moscow State University, Moscow, RUSSIAN FEDERATION, 2Center for Theoretical Problems of Physico-Chemical Pharmacology, Moscow, RUSSIAN FEDERATION, 3Dmitry Rogachev National Research Center of Pediatric Hematology, Oncology and Immunology, Moscow, RUSSIAN FEDERATION, 4Biology, Lomonosov Moscow State University, Moscow, RUSSIAN FEDERATION, 5Federal Research and Clinical Center of Specialized Medical Care and Medical Technologies, Moscow, RUSSIAN FEDERATION, 6MCD Biology, University of Colorado, Boulder, CO.
12:00 pm M87 Regulation of kinesin and dynein motility by tau and MAP7. L. Ferro1, L. Eshun-Wilson2, M. Gölcük3, J. Fernandes1, T. Huijben4, E. Gerber1, Q. Fang1, M. Gur3, E. Nogales1, A. Yildiz1; 1University of California, Berkeley, Berkeley, CA, 2Scripps Research Institute, San Diego, CA, 3Istanbul Technical University, Istanbul, TURKEY, 4Delft University of Technology, Delft, NETHERLANDS.
12:15 pm M88 Distinct FHF complexes link dynein to different intracellular cargos. J. R. Christensen, A. A. Kendrick, A. Aguilar-Maldonado, V. Adani, S. L. Reck-Peterson; University of California, San Diego, La Jolla, CA.
12:30 pm M89 Structure reveals the transformation of Arp2/3 complex from inactive to nucleation-competent state. M. Shaaban1, B. J. Nolen2, S. Chowdhury1; 1Department of Biochemistry and Cell Biology, Stony Brook University, Stony Brook, NY, 2Department of Chemistry and Biochemistry, University of Oregon, Eugene, OR.
12:45 pm M90 Structure-function analysis of the MyTH4-FERM myosins reveals insights into the determinants of actin track selection in polarized epithelia. S. Matoo, M. J. Graves, Z. A. Storad, R. El Sheikh Idris, P. Acharya, B. K. Pickles, P. E. Shinder, T. O. Arvay, S. W. Crawley; Biological Sciences, University of Toledo, Toledo, OH.
Track(s): Communal Cell: Development, Differentiation, Regeneration, Stem Cells, Organs, and Organoids, and Physical Cell: Bioengineering, Mechanobiology, and Synthetic Biology
Co-Chairs: Purushothama Rao Tata, Department of Cell Biology, Duke University School of Medicine, and Mary N. Teruel, Weill-Cornell Medical College, Cornell University
11:30 am M91 Cellular maelstroms and tissue jousting: adventures in millimeter-scale tissue growth and collisions. M. Heinrich, R. Alert, A. Kosmrlj, D. Cohen; Princeton University, Princeton, NJ.
11:45 am M92 Lights, Camera, Action: Investigating the mechanism of Rho flare activation using optogenetics. S. Chumki, R. Stephenson, A. Miller; University of Michigan - Ann Arbor, Ann Arbor, MI.
12:00 pm M93 SWI/SNF chromatin remodeling regulates cell cycle exit and promotes cellular invasion in the C. elegans Anchor Cell. J. J. Smith1, Y. Xiao1, N. Parsan2, A. Q. Kohrman1, N. Weeks1, W. Zhang1, D. Q. Matus1; 1Biochemistry & Cell Biology, Stony Brook University, Stony Brook, NY, 2Massachusetts Institute of Technology, Boston, MA.
12:15 pm M94 Cell fate coordinates mechano-osmotic forces in intestinal crypt morphogenesis. Q. Yang; Friedrich Miescher Institute, Basel, SWITZERLAND.
12:30 pm M95 Reconstituting Epithelial Branching Morphogenesis by Engineering Cell Adhesion. S. Wang, K. Matsumoto, K. M. Yamada; National Institute of Dental and Craniofacial Research, NIH, Bethesda, MD.
12:45 pm M96 Extracellular-forces shaped by tissue stiffness drives inner ear morphogenesis. A. Munjal1, E. Hanezzo2, S. Megason1; 1Systems Biology, Harvard Medical School, Boston, MA, 2Institute of Science and Technology Austria (IST Austria), Klosterneuburg, AUSTRIA.
Track(s): Cellular Genome: 4D Organization, Expression, Replication, and Repair, and Cellular Dynamics: Compartmentalization, Trafficking, Cytoskeleton, Division, and Migration
Co-Chairs: William C. Earnshaw, Wellcome Centre for Cell Biology, University of Edinburgh, UK, and Peter Ly, UT Southwestern Medical Center
11:30 am M97 Evolution of the chromosome proteome during synchronous mitotic entry. I. Samejima, W. C. Earnshaw; Wellcome Centre for Cell Biology, University of Edinburgh, Edinburgh, UNITED KINGDOM.
11:45 am M98 Linker histone regulates mitotic compaction through condensin I and TopoIIα. P. Choppakatla1, B. Dekker2, J. Dekker2,3,4, H. Funabiki1; 1Laboratory of Chromosome and Cell Biology, The Rockefeller University, New York, NY, 2Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA, 3Howard Hughes Medical Institute, Chevy Chase, MD, 4Program in Systems Biology, University of Massachusetts Medical School, Worcester, MA.
12:00 pm M99 Stacking up the centromere: Role of CENP-N in Centromere Chromatin Organization. K. Sundararajan1, M. Gebala1, K. Zhou2 , A. F. Straight1, Karolin Luger2; 1Stanford University, Stanford, CA., 2University of Colorado Boulder, Boulder, CO
12:15 pm M100 Organization and segregation of a highly segmented bacterial genome. C. N. Takacs1, Y. Xiang1, M. Scott2, P. A. Rosa3, C. Jacobs-Wagner1,4; 1Biology, Stanford University, Stanford, CA, 2MCDB, Yale University, New Haven, CT, 3Bacteriology, Rocky Mountain Laboratories, NIAID, NIH, Hamilton, MT, 4The Howard Hughes Medical Institute, Stanford, CA.
12:30 pm M101 Liquid-Liquid Phase Separation Drives Compartmentalization and Protection of Telomeres. Y. Kim1, A. R. Strom2, A. Jack3, D. S. W. Lee4, L. S. Ferro5, A. Yildiz6, C. P. Brangwynne2; 1Molecular Biology, Princeton University, Princeton, NJ, 2Chemical and Biological Engineering, Princeton University, Princeton, NJ, 3Biophysics, University of California Berkeley, Berkeley, CA, 4Quantitative and Computational Biology, Princeton University, Princeton, NJ, 5Molecular and Cellular Biology, University of California Berkeley, Berkeley, CA, 6Physics and Molecular and Cellular Biology, University of California Berkeley, Berkeley, CA.
12:45 pm M102 Regulation of sumoylation is key to condensate formation and telomere clustering in ALT cancer. H. Zhang, R. Zhao, J. Tones; Carnegie Mellon University, Pittsburgh, PA.
Track(s): Cellular Dynamics: Compartmentalization, Trafficking, Cytoskeleton, Division, and Migration, and Physical Cell: Bioengineering, Mechanobiology, and Synthetic Biology
Co-Chairs: Rafael Garcia-Mata, Department of Biological Sciences, University of Toledo, and Minna Roh-Johnson, Department of Biochemistry, University of Utah
11:30 am M103 Exogenous and endogenous extra-chromosomal DNA is sorted into a novel cytoplasmic compartment in mammalian cells. L. Schenkel, X. Wang, N. Le, M. Burger, A. Bailllifard, L. Hug, L. Gillet, Y. Barral, R. Kroschewski; ETH Zurich, Zurich, SWITZERLAND.
11:45 am M104 Emergence of synchronized multicellular mechanosensing from spatiotemporal integration of heterogeneous single-cell information transfer. A. Zamir1, G. Li2, K. Chase3, R. Moskovitch1, B. Sun2, A. Zaritsky1; 1Ben-Gurion University of the Negev, Beer-Sheva, ISRAEL, 2Oregon State University, Corvallis, OR, 3Princeton University, Princeton, NJ.
12:00 pm M105 In vivo Analysis of Focal Adhesion like Structures During Single Cell Migration. Q. Xue, J. Carrington, M. Roh-Johnson; University of Utah, Salt Lake City, UT.
12:15 pm M106 Neural crest EMT is controlled via target degradation within P-bodies. E. J. Hutchins, M. L. Piacentino, M. E. Bronner; California Institute of Technology, Pasadena, CA.
12:30 pm M107 Changes in neighbor cell contractility alter the speed and success of epithelial cytokinesis. J. Landino, E. Misterovich, S. Chumki, A. L. Miller; University of Michigan, Ann Arbor, MI.
12:45 pm M108 C. elegans reveal a connection between the tissue organizers MLT-4/inversin and the clathrin adaptor AP2. G. M. Beacham, G. Hollopeter; Cornell University, Ithaca, NY.
Track(s): Cells in Distress and Disease: Cancer, Aging, Infection, Stress, Chemical Biology, and Therapeutics, and Cellular Dynamics: Compartmentalization, Trafficking, Cytoskeleton, Division, and Migration
Co-Chairs: Roberto Bruzzone, HKU-Pasteur Research Pole, School of Public Health, The University of Hong Kong, Hong Kong SAR, and Paul de Figueiredo, Department of Microbiology and Immunology, Texas A&M Health Science Center
11:30 am M109 Highway to Cell: Rab11a mediates cell-cell spread of influenza A virus genomes via tunneling nanotubes. K. Ganti, A. C. Lowen; Emory University School of Medicine, Atlanta, GA.
11:45 am M110 The Cytosol of Intestinal Epithelial Cells Is an Important Reservoir for SalmonellaPersistence and Fecal Shedding. A. Chong, K. Cooper, L. Kari, O. Steele-Mortimer; Rocky Mountain Laboratories, NIAID, NIH, Hamilton, MT.
12:00 pm M111 The antiviral sirtuin 3 bridges protein acetylation to mitochondrial integrity and metabolism during human cytomegalovirus infection. X. Sheng, I. M. Cristea; Department of Molecular Biology, Princeton University, Princeton, NJ.
12:15 pm M112 Manipulating PrP glycan structure to understand toxic signaling pathways driving prion-induced neurodegeneration. J. A. Callender1, A. M. Sevillano1, D. B. McClatchy2, K. Soldau1, H. Khuu1, T. Kurt1, J. R. Yates, III2, C. J. Sigurdson1; 1Pathology, University of California, San Diego, San Diego, CA, 2Chemical Physiology and Molecular and Cellular Molecular Biology, Scripps Research Institute, La Jolla, CA.
12:30 pm M113 Determining the Role of Multiple Endocytic Pathways in Promoting Listeria monocytogenes epithelial cell-to-cell spread. P. Radhakrishnan1, F. Ortega2, J. Theriot3; 1Biophysics, Stanford University, Stanford, CA, 2Biochemistry, Stanford University, Stanford, CA, 3Biology, University of Washington, Seattle, WA.
12:45 pm M114 Functional single-cell genomics of human cytomegalovirus infection. M. Y. Hein1,2, J. S. Weissman3,2; 1Chan Zuckerberg Biohub, San Francisco, CA, 2University of California San Francisco, San Francisco, CA, 3Whitehead Institute, Cambridge, MA.
Track(s): Signaling and Metabolism: Integrating Intra- and Intercellular Signaling, and Information Processing, and Cells in Distress and Disease: Cancer, Aging, Infection, Stress, Chemical Biology, and Therapeutics
Co-Chairs: Brooke Emerling, Sanford Burnham Prebys Medical Discovery Institute, and Alexander Muir, University of Chicago
11:30 am M115 Adipose tissue nutrient sensing in the control of oocyte production using Drosophila melanogaster as a model. A. R. Armstrong; Biological Sciences, University of South Carolina, Columbia, SC.
11:45 am M116 Pre-mRNA Splicing Control of Mitochondria and Energy Metabolism. A. A. Jourdain1,2, B. E. Begg3, E. Mick1,4, H. Shah1,4, S. E. Calvo1,4, O. S. Skinner1,4, R. Sharma1,4, S. M. Blue5, G. W. Yeo5, C. B. Burge3, V. K. Mootha1,4,6; 1BROAD INSTITUTE OF MIT AND HARVARD, Cambridge, MA, 2Massachusetts General Hospital, Boston, MA, 3Massachusetts Institute of Technologies, Cambridge, MA, 4Massachusetts General Hospital, Cambridge, MA, 5UCSD, San Diego, CA, 6Howard Hughes Medical Institute, Boston, MA.
12:00 pm M117 PCK2 balances TCA cycle flux and mitochondrial respiration to maintain the redox equilibrium in starved lung cancer cells. G. Grasmann1, M. Planque2, C. T. Madreiter Sokolwski3,4, W. F. Graier3, T. Madl3,5, A. Springer3, A. Hrzenjak1,6, H. Olschewski1,6, S. M. Fendt2, K. Leithner1; 1Division of Pulmonology, Medical University of Graz, Graz, AUSTRIA, 2Laboratory of Cellular Metabolism and Metabolic Regulation, VIB, KU Leuven Center for Cancer Biology, Leuven, BELGIUM, 3Gottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Medical University of Graz, Graz, AUSTRIA, 4Energy Metabolism Laboratory, Institute of Translational Medicine, Department of Health Sciences a, Swiss Federal Institute of Technology (ETH), Zurich, SWITZERLAND, 5BioTechMed Graz, Graz, AUSTRIA, 6Ludwig Boltzmann Institute for Lung Vascular Research, Graz, AUSTRIA.
12:15 pm M118 Maladaptive nutrient signalling sustains the m.3243A>G mtDNA mutation. C. Chung1, K. Singh1, V. N. Kotiadis1, J. Ahn1, L. Kabir1, E. Topley1, J. Tan1, W. D. Andrews1, N. Plotegher1, G. Guella2, R. D. S. Pitceathly1, G. Szabadkai1, M. Yuneva3, M. R. Duchen1; 1University College London, London, UNITED KINGDOM, 2Department of Physics, University of Trento, Trento, ITALY, 3The Francis Crick Institute, London, UNITED KINGDOM.
12:30 pm M119 The cell cycle-related kinase AURKA forms a tripartite complex with PHB2 and LC3 to select metabolically-competent mitochondria by mitophagy. G. Bertolin1, M. Alves-Guerra2, A. Burel3, C. Prigent1, R. Le Borgne1, M. Tramier1; 1Univ Rennes, CNRS, IGDR (Genetics and Development Institute of Rennes), UMR 6290, F-35000, Rennes, FRANCE, 2Université de Paris, Institut Cochin, INSERM, CNRS F-75014, Paris, FRANCE, 3Univ Rennes, MRic CNRS, INSERM, SFR Biosit, UMS 3480, F-35000, Rennes, FRANCE.
12:45 pm M120 Diversity in mTORC1 substrate recruitment enables specificity of metabolic responses to nutritional cues. G. Napolitano1, C. Di Malta1, A. Esposito1, M. E. G. de Araujo2, S. Pece3, G. Bertalot3, M. Matarese1, V. Benedetti1, A. Zampelli1, T. Stakys2, D. Siciliano1, A. Venuta1, M. Cesana1, C. Vilardo1, E. Nusco1, J. Monfregola1, A. Calcagnì1, P. P. Di Fiore3, L. A. Huber2, A. Ballabio1; 1TIGEM, Pozzuoli, ITALY, 2University of Innsbruck, Innsbruck, AUSTRIA, 3IEO, Milan, ITALY.
Track(s): Cellular Dynamics: Compartmentalization, Trafficking, Cytoskeleton, Division, and Migration, and Signaling and Metabolism: Integrating Intra- and Intercellular Signaling, and Information Processing
Co-Chairs: Samantha Cleopatra Lewis, Department of Molecular and Cell Biology, UC Berkeley, and Yasunori Saheki, Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore
11:30 am M121 Actin polymerization around depolarized mitochondria disrupts ER-mitochondrial contact, delaying Parkin accumulation and mitophagy. R. Chakrabarti, T. Fung, H. N. Higgs; Geisel School of Medicine at Dartmouth, Hanover, NH.
11:45 am M122 New insight into EGFR signaling regulation by the LIN-2/7/10 complex in C. elegans. K. D. Gauthier1,2, C. E. Rocheleau1,2,3; 1Metabolic Disorders and Complications, Research Institute of the MUHC, Montreal, QC, CANADA, 2Anatomy and Cell Biology, McGill University, Montreal, QC, CANADA, 3Medicine, McGill University, Montreal, QC, CANADA.
12:00 pm M123 Direct PA-binding by Chm7 is required for nuclear envelope surveillance at herniations. D. Thaller1, D. Tong1, C. Marklew2, P. Mannino1, N. Ader1, M. C. King1, B. Ciani2, P. Lusk1; 1Cell Biology, Yale University Sch Med, New Haven, CT, 2Chemistry, University of Sheffield, Sheffield, UNITED KINGDOM.
12:15 pm M124 Nir1 is a Novel ER-PM Junction Tether and a Positive Regulator of PM PI(4,5)P2. C. Quintanilla, J. Liou; Physiology, UT Southwestern Medical Center, Dallas, TX.
12:30 pm M125 Endolysosome motility is restricted by SNX19-mediated membrane contacts with the endoplasmic reticulum. A. Saric1, S. Freeman2, C. Williamson1, M. Jarnik1, C. M. Guardia1, M. S. Fernandopulle3, D. Gershlick4, J. S. Bonifacino1; 1National Institute of Child Health and Human Development, NIH, Bethesda, MD, 2Hospital for Sick Children, Toronto, ON, CANADA, 3National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD, 4Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UNITED KINGDOM.
12:45 pm M126 Last step in the path of LDL cholesterol from lysosome to plasma membrane to ER is governed by phosphatidylserine. M. N. Trinh1, M. S. Brown1, J. L. Goldstein1, J. Han2, G. Vale3, J. G. McDonald3, J. Seemann4, J. T. Mendell2, F. Lu1; 1Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX, 2Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX, 3Center for Human Nutrition, University of Texas Southwestern Medical Center, Dallas, TX, 4Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX.
Friday, December 11, 11:30 am to 1:00 pm EST
Track(s): Cells in Distress and Disease: Cancer, Aging, Infection, Stress, Chemical Biology, and Therapeutics, and Cellular Dynamics: Compartmentalization, Trafficking, Cytoskeleton, Division, and Migration
Co-Chairs: Martina Bazzaro, Department of Department of Obstetrics, Gynecology and Women's Health, Masonic Cancer Center University of Minnesota, and Marie R. Webster, Lankenau Institute for Medical Research
11:30 am M127 A new concept explaining the cell biology of axons and axon pathology. I. Hahn1, A. Voelzmann1, Y. Qu1, N. Sánchez-Soriano2, A. Prokop1; 1The University of Manchester, Manchester, UNITED KINGDOM, 2University of Liverpool, Liverpool, UNITED KINGDOM.
11:45 am M128 Machine learning predicts states of aging based on emergent single-cell mechanical phenotypes. S. Hinz1, M. Miyano1, J. C. Lopez1, L. L. Sohn2, M. A. LaBarge1; 1Population Science, City of Hope, Duarte, CA, 2Department of Mechanical Engineering, University of California at Berkeley, Berkeley, CA.
12:00 pm M129 Cilia on muscle stem cells are critical to maintain regenerative capacity and are lost during aging. A. R. Palla1, K. I. Hilgendorf1, A. V. Yang1, J. P. Kerr2, A. C. Hinken2, J. Demeter1, P. Kraft1, N. A. Mooney1, N. Yucel1, P. K. Jackson1, H. M. Blau1; 1Baxter Laboratory for Stem Cell Biology, Department of Microbiology and Immunology, Stanford University, Stanford, CA, 2Muscle Metabolism Discovery Performance Unit, GlaxoSmithKline, Collegeville, PA.
12:15 pm M130 Mitochondrial Homeostasis Is Maintained in the Absence of Autophagy. C. Towers, D. Wodetzki, J. Thorburn, C. Caino, K. Smith, A. Thorburn; Pharmacology, University of Colorado, Denver AMC, Denver, CO.
12:30 pm M131 Macrophage activation alters mitochondrial morphology and promotes mitochondrial transfer to cancer cells. J. R. Casalini, C. U. Kidwell, J. S. Johnson, M. Roh-Johnson; Biochemistry, University of Utah, SALT LAKE CITY, UT.
12:45 pm M132 Accelerating Drug Discovery through the Power of Cell Morphology. A. Carpenter; Broad Institute, Cambridge, MA.
Track(s): Specialized Cell and Evolution: Neurobiology, Immunology, and Emerging Model Systems, and Physical Cell: Bioengineering, Mechanobiology, and Synthetic Biology
Co-Chairs: Nicolas E. Buchler, Department of Molecular Biomedical Sciences, North Carolina State University, and Annika Guse, Cell Biology of Endosymbiosis, Centre for Organismal Studies Heidelberg, Germany
11:30 am M133 C. elegansreads bacterial non-coding RNAs to learn pathogenic avoidance. R. S. Moore, R. Kaletsky, C. T. Murphy; Molecular Biology, Princeton University, Princeton, NJ.
11:45 am M134 When plants and animals become one: Organismal and cellular interactions in a vertebrate-alga symbiosis. J. A. Burns1, H. Yang2, R. Adikes3, C. Loussert4, R. T. Williamson5, B. Genot1, W. Strangman5, C. Alves-de-Souza5, D. Q. Matus3, S. Duhamel2, R. Kerney6; 1Bigelow Laboratory for Ocean Sciences, East Boothbay, ME, 2University of Arizona, Tucson, AZ, 3Stony Brook University, Stony Brook, NY, 4École polytechnique fédérale de Lausanne, Lausanne, SWITZERLAND, 5University of North Carolina Wilmington, Wilmington, NC, 6Gettysburg College, Gettysburg, PA.
12:00 pm M135 Cellular and developmental insights into the evolution of myocytes: insights from sponges. J. J. Colgren, S. A. Nichols; UNIVERSITY OF DENVER, DEPARTMENT OF BIOLOGICAL SCIENCES, Denver, CO.
12:15 pm M136 Evolution of cell contractility and the origin of animal morphogenesis: insights from choanoflagellates. T. Brunet, N. King; University of California, Berkeley, Berkeley, CA.
12:30 pm M137 Evolutionarily conserved mechanisms governing branched morphology in the aggregatively multicellular Rhizarian amoeba, Filoreta ramosa. S. Guest, S. Dawson; UC Davis, Davis, CA.
12:45 pm M138 Evolutionary principles for the actions of molecular machines. J. Wagoner; Laufer Center for Physical and Quantitative Biology, Stony Brook University, Stony Brook, NY.
Track(s): Cellular Genome: 4D Organization, Expression, Replication, and Repair, and Cells in Distress and Disease: Cancer, Aging, Infection, Stress, Chemical Biology, and Therapeutics
Co-Chairs: Abigail L. Buchwalter, Cardiovascular Research Institute, University of California, San Francisco, and Joseph Rodriguez, Epigenetics & Stem Cell Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health
11:30 am M139 Synthetic regulatory genomics of mammalianHoxclusters. S. Pinglay; NYU School of Medicine, New York, NY.
11:45 am M140 Arginine methylation promotes siRNA-binding specificity for a spermatogenesis-specific isoform of the Argonaute protein CSR-1. D. H. Nguyen, C. M. Phillips; Biological Sciences, USC, Los Angeles, CA.
12:00 pm M141 Building a nuclear state landscape in human iPSCs: integrated analysis of the organization and function of nuclear bodies. C. L. Frick, S. M. Rafelski; Allen Institute for Cell Science, Seattle, WA.
12:15 pm M142 DNA damage induces divergent response in chromatin dynamics at break sites and in undamaged regions of the cell nucleus. M. Locatelli1, J. Lawrimore2, H. Lin3, C. Seitz3, P. Kefer4, G. Holzwarth4, K. Bonin4, K. Bloom2, J. Liu3, P. Vidi1; 1Wake Forest School of Medicine, Winston Salem, NC, 2University of North Carolina, Chapel Hill, NC, 3Indiana university-Purdue University Indianapolis, Indianapolis, IN, 4Wake Forest University, Winston Salem, NC.
12:30 pm M143 “When bigger is not better”: Whole genome duplication generates DNA damage by compromising DNA replication dynamics. S. Gemble1, M. Nano2, R. Basto1; 1Institut Curie, Paris, FRANCE, 2University of California, Santa Barbara, CA.
12:45 pm M144 Sonic hedgehog accelerates DNA replication and causes replication stress. L. Tamayo Orrego1, A. P. Jackson1, G. W. Brown2, F. Charron3; 1MRC Human Genetics Unit, University of Edinburgh-89047877, Edinburgh, UNITED KINGDOM, 2Biochemistry, University of Toronto, Toronto, ON, CANADA, 3IRCM, Montreal, QC, CANADA.
Track(s): Cellular Dynamics: Compartmentalization, Trafficking, Cytoskeleton, Division, and Migration
Co-Chairs: Alex Nechiporuk, Department of Cell, Developmental & Cancer Biology, OHSU, and Nick Rhind, UMass Medical School
11:30 am M145 E-cadherin-mediated cell contacts underlie epithelial symmetry breaking in vivo. V. Naturale, J. Feldman; Stanford University, Stanford, CA.
11:45 am M146 Cell-cycle-dependent cues temporally regulate Cdc42 activity at growth sites in fission yeast. J. Rich-Robinson, A. Russell, E. Mancini, M. Das; Biochemistry & Cellular and Molecular Biology, University of Tennessee, Knoxville, Knoxville, TN.
12:00 pm M147 Coupling between protrusion dynamics and polarized secretion steers persistent cell migration. K. Vaidziulyte1,2, K. Schauer1, M. Coppey1; 1Institut Curie, Paris, FRANCE, 2Sorbonne Université, Paris, FRANCE.
12:15 pm M148 Autophagosomal maturity coordinates dynein effector scaffolding in axons. S. E. Cason1, P. J. Carman2, C. Van Duyne3, R. Dominguez4, E. L. F. Holzbaur1; 1Physiology, Neuroscience Graduate Group, Pennsylvania Muscle Institute, University of Pennsylvania, Philadelphia, PA, 2Physiology, Biochemistry & Molecular Biophysics Graduate Group, Pennsylvania Muscle Institute, University of Pennsylvania, Philadelphia, PA, 3Vagelos Program in Molecular Life Sciences, University of Pennsylvania, Philadelphia, PA, 4Physiology, University of Pennsylvania, Philadelphia, PA.
12:30 pm M149 A novel role of presynaptic periactive zone proteins in extracellular vesicle trafficking. A. L. Scalera1, C. R. Blanchette1, Z. Zhao1, K. Harris2, K. Koles1, A. Yeh1, J. K. Apiki1, B. A. Stewart2, A. Rodal1; 1Brandeis University, Waltham, MA, 2University of Toronto, Toronto, ON, CANADA.
12:45 pm M150 A kink in brain development: Altering tubulin’s conformational transitions disrupts neuronal morphology and migration. K. J. Hoff, J. E. Aiken, M. A. Gutierrez, S. J. Franco, J. K. Moore; University of Colorado, Aurora, CO.
Track(s): Physical Cell: Bioengineering, Mechanobiology, and Synthetic Biology, and Cellular Dynamics: Compartmentalization, Trafficking, Cytoskeleton, Division, and Migration
Co-Chairs: Jian Liu, Center for Cell Dynamics, Department of Cell Biology, School of Medicine, Johns Hopkins University, and Wanda Strychalski, Department of Mathmatics, Applied Mathematics and Statistics, Case Western Reserve University
11:30 am M151 Cell surface mechanics gate stem cell differentiation. M. Bergert1, S. Lembo1, S. Sharma2, L. Russo1, D. Milovanović1, K. Gretarsson3, M. Börmel4, P. Neveu1, J. Hackett3, E. Petsalaki2, A. Diz-Muñoz1; 1EMBL, Heidelberg, GERMANY, 2EMBL - EBI, Hinxton, UNITED KINGDOM, 3EMBL, Monterotondo, ITALY, 4EMBL - Electron Microscopy Core Facility, Heidelberg, GERMANY.
11:45 am M152 Membrane Ruffling Allows Cells to Sense and Respond to Changes in Viscosity. M. Pittman, K. Li, J. Chen, M. Wang, Y. Chen;
Johns Hopkins University, Baltimore, MD
12:00 pm M153 Mechanisms of actin force production in clathrin-mediated endocytosis revealed by integrating mathematical modeling with in situ cryo-electron tomography. M. Akamatsu1, D. Serwas1, A. Moayed1, R. Vasan2, K. Vegesna1, J. Hill1, J. Schoeneberg1, K. M. Davies3, P. Rangamani2, D. G. Drubin1; 1Molecular and Cellular Biology, UC Berkeley, Berkeley, CA, 2Mechanical and Aerospace Engineering, UC San Diego, La Jolla, CA, 3Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA.
12:15 pm M154 Spectrins stabilize extracellular and intracellular polymer networks to regulate endothelial shear responses. S. Mylvaganam, S. Freeman, S. Grinstein; Biochemistry, University of Toronto, Toronto, ON, CANADA.
12:30 pm M155 The balance between actomyosin contractility and microtubule polymerization regulates hierarchical protrusions that govern efficient fibroblast-collagen interactions. D. Shakiba1, F. Alisafaei2, A. Savadipour1, R. Rowe1, Z. Liu1, K. Pryse1, V. Shenoy2, E. Elson1, G. Genin1; 1Washington University in St. Louis, St. Louis, MO, 2University of Pennsylvania, Philadelphia, PA.
12:45 pm M156 Actin polymerization controlled by mechanical force protects the cytoskeleton from damage and facilitates stress fiber repair. F. R. Valencia1, E. Sandoval2, J. Liu2, S. V. Plotnikov1; 1Department of Cell and Systems Biology, University of Toronto, Toronto, ON, CANADA, 2Center for Cell Dynamics, Department of Cell Biology, Johns Hopkins University, Baltimore, MD.
Track(s): Cellular Dynamics: Compartmentalization, Trafficking, Cytoskeleton, Division, and Migration, and Physical Cell: Bioengineering, Mechanobiology, and Synthetic Biology
Co-Chairs: Johanna Ivaska, Molecular Cell Biology, Turku Bioscience Center, University of Turku, Finland, and Ronen Zaidel-Bar, Tel Aviv University, Israel
11:30 am M157 The ESCRT machinery counteracts Nesprin-2G-mediated cytoskeletal forces during nuclear envelope repair. S. S. Wallis1, L. N. Ventimiglia1, E. Infante1, M. A. Cuesta-Geijo1, G. R. Kidiyoor2, M. A. Carbajal1, R. A. Fleck1, M. Foiani2, S. Garcia-Manyes1, J. Martin-Serrano1, M. Agromayor1; 1King's College London, London, UNITED KINGDOM, 2IFOM, Milan, ITALY.
11:45 am M158 Tension promotes kinetochore-microtubule release by Aurora B kinase. G. Chen1, F. Renda2, H. Zhang3, A. Gokden1, D. Z. Wu1, D. M. Chenoweth1, A. Khodjakov2, M. Lampson1; 1University of Pennsylvania, Philadelphia, PA, 2Wadsworth Center, Albany, NY, 3Carnegie-Mellon University, Pittspurgh, PA.
12:00 pm M159 Caveolae control membrane tension during cytokinesis and promote successful abscission. V. Ribeiro De Andrade1, J. Bai1, N. Gupta1, A. Jimenez2, C. Lamaze2, A. Echard1; 1Institut Pasteur, Paris, FRANCE, 2Institut Curie, Paris, FRANCE.
12:15 pm M160 Mechanism of cell-cell fusion induced by a bacterial pathogen. N. Kostow, M. D. Welch; Molecular & Cell Biology, UC Berkeley, Berkeley, CA.
12:30 pm M161 Coordinated trafficking of VE-cadherin for endothelial migration and angiogenesis. T. Malinova1, A. Angulo Urarte1, J. Nuchel2, M. Tauber2, M. Graupera3, M. Plomann2, S. Huveneers1; 1University of Amsterdam, Amsterdam UMC, Amsterdam, NETHERLANDS, 2University of Cologne, Cologne, GERMANY, 3Institut d´Investigació Biomèdica de Bellvitge, Barcelona, SPAIN.
12:45 pm M162 Canoe/Afadin and Abl are required for mechanotransduction at tricellular junctions. H. H. Yu, J. A. Zallen; Sloan Kettering Institute/HHMI, New York, NY.
Track(s): Signaling and Metabolism: Integrating Intra- and Intercellular Signaling, and Information Processing, and Cellular Dynamics: Compartmentalization, Trafficking, Cytoskeleton, Division, and Migration
Co-Chairs: Yulia A. Komarova, Department of Pharmacology, University of Illinois College of Medicine, and Damaris N. Lorenzo, Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill
11:30 am M163 Temporal changes in lipid metabolism control neural crest epithelial-to-mesenchymal transition and plasma membrane fluidity. M. L. Piacentino1, E. J. Hutchins1, E. Sezgin2,3, C. J. Andrews1, T. Sauka-Spengler3, M. E. Bronner1; 1Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, 2Science for Life Laboratory, Department of Women's and Children's Health, Karolinska Institute, Solna, SWEDEN, 3MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UNITED KINGDOM.
11:45 am M164 Elucidating the integration of metabolism with oncogenic signals in a Drosophila tumour model. E. M. Verheyen, K. K. L. Wong, J. Z. Liao, C. R. Y. Shih, N. Harden; Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC, CANADA.
12:00 pm M165 Lysosome signaling induces mitochondrial itaconate to suppress permissive bacterial growth niches. A. S. Rambold, E. Schuster, K. Lucht; Max Planck Institute of Immunobiology and Epigenetics, Freiburg, GERMANY.
12:15 pm M166 NPC1-mTORC1 signaling Couples Cholesterol Sensing to Organelle Homeostasis and is a Targetable Pathway in Niemann-Pick type C. O. B. Davis1, H. R. Shin1, C. Lim1, E. Y. Wu2, M. Kukurugya1, C. F. Maher1, R. M. Perera3, M. Ordonez2, R. Zoncu1; 1University of California, Berkeley, Berkeley, CA, 2University of California, San Diego, La Jolla, CA, 3University of California, San Francisco, San Francisco, CA.
12:30 pm M167 Trypanosoma brucei Tim50, a Mitochondrial Protein Translocase, Acts as a Virulence Factor for the Parasite. M. Chaudhuri, A. Tripathi, U. Singha; Microbiology, Immunology, and Physiology, Meharry Medical College, Nashville, TN
12:45 pm M168 HD-PTP deficient mouse exhibits lipodystrophy. B. A. Davies1, Z. He1, C. P. Martin1, S. K. Jachim1, J. A. Payne1, C. Zhang2, B. G. Childs3, H. Li2, M. A. Davies4, J. M. van Deursen3, D. J. Katzmann1; 1Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, 2Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, 3Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN, 4Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX
Minisymposium Co-Chair Responsibilities & Guidelines
Minisymposium Co-Chair Responsibilities
Minisymposium Co-Chairs are responsible for reviewing abstracts, assigning talks to Minisymposia sessions, and introducing the speakers on the day of the Minisymposium. Minisymposia Co-Chairs are not eligible to speak in their session.
A minimum of six (6) and a maximum of 12 Minisymposium Co-Chairs will be selected per scientific meeting track.
Minisympsium Co-Chairs will:
- Review and score up to 150 abstracts submitted to their scientific track. The review period will take place between August 12 and August 24.
- Create a specified number of Minisymposia sessions, with help by the Program Committee Track Chairs. Each Minisymposium session will consist of six (6) talks, based on the top-scoring abstracts.
- Chair the session at Cell Bio Virtual 2020. Co-Chairs will work together to introduce the speakers in each Minisymposium.
Availability Requirements
Minisymposium Co-Chairs must be available during the following time periods
- Wednesday, August 12 through Monday, August 24 - Abstract Review Period
- Saturday, December 5 through Friday, December 11 - Available virtually on the day of Minisymposium at a designated date and time
Minisymposium Co-Chair Application Requirements
- All applicants are required to login with your ASCB account first. If you do not have an account, you will need to create one before applying.
- You must:
- Select a primary scientific track, with an optional secondary scientific track.
- Provide a link to your lab website
- Write a Research Impact Statement (200-300 words) - a summary of your research, highlighting your top accomplishments over the last five years.
- Explain why you are applying to be a Minisymposium Co-Chair (125 words or less)