Join us December 14-18, 2024 in San Diego, California for Cell Bio 2024, the joint meeting of ASCB and the European Molecular Biology Organization (EMBO). This is your opportunity to network with scientists, present your research, explore the exhibit hall, and learn the latest cell biology science and technology.
Preprint Highlight: Telomeric DNA breaks in human induced pluripotent stem cells trigger ATR-mediated arrest and telomerase-independent telomere length maintenance
Dysfunctional telomeres in differentiated cells activate the ATM (ataxia telangiectasia-mutated)-dependent DNA damage response (DDR), leading to cell cycle arrest. However, the response of stem cells to telomere DNA damage remains poorly understood. The authors used inducible expression of the nuclease FokI fused to the telomere protein TRF1 in human induced pluripotent stem cells (iPSCs), to induce…
Preprint Highlight: mRNA Location and Translation Rate Determine Protein Targeting to Dual Destinations
NET1 is a guanine nucleotide exchange factor for RhoA GTPase that plays different roles in the nucleus and cytoplasm. While perinuclear and peripheral mRNA translation sites have been identified, the mechanisms of spatial translation regulation and impacts on protein function are not generally understood. Here, the authors use genetic tools to manipulate NET1 mRNA targeting…
Preprint Highlight: Contractile ring mechanosensation and its anillin-dependent tuning during early embryogenesis
Dividing cells assemble and constrict a contractile ring made up of actin and myosin anchored to the cell cortex. How the contractile ring senses the mechanics of the cell cortex is not known. With asymmetric ring closure in C. elegans as a model, the authors used novel 4D imaging and image segmentation methods to carefully track ring…
Preprint Highlight: Age-dependent loss of cohesion protection in human oocytes
Age-dependent loss of cohesion is a determinant of aneuploidy in human oocytes. Mechanisms for how this loss is triggered with age are not known. Using oocytes from human participants of various ages, the authors correlate loss of Sgo2, a protector of cohesins, with age-related meiosis II cohesion defects including increased inter-kinetochore distances and single chromatids….
Preprint Highlight: 7-UP: generating in silico CODEX from a small set of immunofluorescence markers
Multiplexed molecular imaging enables the characterization of the spatial organization of different cell types in their native tissue context but is an expensive and labor-intensive technology. This study presents 7-UP, a method that computationally generates 40 protein expression markers, at single-cell resolution, from a panel of seven experimentally measured multiplexed immunofluorescence markers. The method relies…
Preprint Highlight: Learning orientation-invariant representations enables accurate and robust morphologic profiling of cells and organelles
One application of deep learning in analysis of cell biological microscopy data is developing meaningful quantitative representations of cellular and/or molecular phenotypic signatures. Because image orientation has no relevance for shape and morphology, encoding orientation within such representations confounds downstream analyses. This study presents O2-VAE, a neural method for learning orientation-invariant, image-based shape representations. The…
Molecular Biology of the Cell (MBoC)
Molecular Biology of the Cell (MBoC) is a premier journal for research in all areas of cell biology, from biophysics to genetics to neuroscience. Its 14 online issues per year include Special Issues in the important areas of Quantitative Cell Biology, and Forces on and within Cells. Readers and authors alike benefit from the journal’s review process, which offers authors constructive feedback by working scientists.
CBE—Life Sciences Education (LSE)
CBE—Life Sciences Education (LSE) is a peer-reviewed journal of life science education research and evidence-based practice published by the ASCB in editorial partnership with the Genetics Society of America and partially funded by Howard Hughes Medical Institute. Online and completely free, LSE emphasizes teaching innovations and evidence of their effectiveness and is designed for educators at all levels and across all life science disciplines.
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